This series is a spin-off from the long running BBC medical drama Casualty. Set in the same hospital as its sister series, this show follows the everyday lives, professional and personal, of the doctors, nurses and patients who find themselves, for various reasons, in the wards of Holby City General Hospital.
Hungover Jasmine desperately tries to step up her game in order to win Ric over. Zosia refuses to emotionally engage with a terminally ill patient who reminds her of Arthur. Raf is positive about stepping up his career, but when a charismatic female patient comes in, he questions whether he should actually be spending more time living his life instead of putting work first.
Zosia's behaviour continues to spiral out of control leading Jac to become concerned for her. Morven faces her fears when she takes charge of a charming patient.
Ric has been suspended and Tristan is on the prowl. An ever watchful Hanssen pays a heavy price when he takes Jasmine under his wing. When Ollie doubts a patient's credibility and questions Zosia's judgment, the ex-lovers clash. Determined to protect Zosia at any cost, Ollie is blown away by a startling revelation. Aware that she is subject of gossip and struggling to manage her feelings for Bernie, Serena is unprepared for what unfolds on AAU.
After saving a life in a near-death trauma case, an overconfident Morven clashes with Raf when he is not convinced that her motives are purely professionally. When Tristan asks Guy for a personal favour, Zosia warns Guy that Tristan is not to be trusted. But Guy strikes a deal with Tristan and his reputation hangs in the balance. When his living habits are called into question, a determined Dominic fights to prove his worth to Isaac but is unprepared for the consequences of his actions.
Part one of two. Guy's plans for his much anticipated Neurosurgical Unit are put in jeopardy when he makes a shocking discovery about Tristan Wood - the Unit's main benefactor. Meanwhile, Serena considers re-kindling her romance with a smitten Robbie but, with Bernie in her thoughts, can she commit to happy ever after with him? And Ric is pressurised to undermine everything he's worked for by Tristan.
Part two of two. A conflicted Guy fights to save Tristan's life, and Raf's budding relationship with Kim is tested when he makes a shocking discovery. Meanwhile, spurred by evidence of Essie's romantic conquests, Sacha tries online dating, but is it really a good match for him?
Dom stoops to low levels to land an assistant's position after Isaac gets a research grant. Elsewhere, Inga fights for her fiancé attention, and Bernie returns
Matteo's arrival irritates Jac and when the medic discovers his past misdemeanours, she throws down the gauntlet. Elsewhere, Dominic gets emotionally embroiled in a challenging case.
Jac puts her patient before her own health concerns, with serious consequences. Elsewhere Raf is taken aback when Parker is brought into hospital and is concerned about the boy's welfare.
When Kim gets positive news regarding her kidney treatment, Essie must deal with the imminent departure of Parker, who has been staying with her. Ollie is devastated when Matteo reveals he plans to ask Zosia out. Morven struggles to master her role as teacher, particularly with the unruly Cameron.
A terrifying blast from the past upsets Dom's plans for the perfect Christmas with Isaac, while Jac pushes her closest friend away as she waits on some Life changing news.
Mo strives to suppress her true feelings for Mr T, Jasmine is given her last chance on the Acute Assessment Unit, while Essie and Raf comes to blows after a difficult patient.
When Mo uncovers a secret, Mr T and Inga's Swedish-Style wedding takes a dark turn, While Serena, Elinor and Jason are involved in a car accident.
Oliver must compete for both funding and Jac's support when Matteo pitches a tempting rival project, and Dominic tries to keep his relationship with Isaac a secret from his parents.
Sacha becomes suspicious about Essie and Raf's relationship, and Fletch fights to save his friend Artem's life when the old gambler returns to the Acute Assessment Unit (AAU)
Mo returns from maternity leave and drops a bombshell, while Dominic gets a shock when he realises that going to Hawaii with Isaac is not going to be as straightforward as he hoped.
A grief-striker Derena returns to work looking for answers and Dominic is in turmoil when Isaac reveals a devastating betrayal. Meanwhile, Ollie and Zosia question if they are ready for the next stage in their relationships.
A familiar face makes a return under shocking circumstances, and grief-stricken Serena takes an eager Jasmine under her wing, but both get more than they bargained for.
Jac may finally acknowledge her feelings for Matteo, and Bernie sees through Serena's attempts to keep everything normal. Meanwhile, Raf is determined to remain professional when Kim reached out for help.
Isaac's dark side comes to surface as his relationship with Dom reaches breaking point, and Serena's mentoring of Jasmine gives Morven cause for concern.
Raf enthusiastically makes plans for the future with Kim and the twins he is to be a father of. However, his hopes and dreams looks set to be dashed by a series of revelations.
Jasmine fights chronic fatigue while trying to impress Serena, Essie wants to become Parker's foster mother, and Oliver tries to maintain his new zen outlook when rivals Jac and Matteo receive project funding.
Dominic's trust in Issac is rocked when a patient they both know is abandoned at the hospital having overdosed, and Fletch makes a shocking discovery about the man Morven has been messaging.
Essie is shocked when Parker turns up with a friend, while Zosia is harbouring a secret from Ollie and is horrified to learn that Isaac knows what it is.
Isaac lashes out when Dom questions their relationship, Serena is dealt a further blow after Elinor's death, and a drunken mistake prompts Ollie to take a big step in his relationship with Zosia.
Serena faces her demons and comes to a heart-wrenching conclusion, Zosia takes action when Issac reveals his true colours, and Mo risks her professional reputation.
Dominic and Isaac's toxic relationship finally reaches boiling point, Fletch's world is shattered by a life-changing revelation, while Matteo tries to reunite Jac and Jasmine.
Jac and Matteo's relationship seem to be heading in the right direction, but when she becomes suspicious of his motives, her investigation unearth skeletons in his closet.
Matteo and Jac clash over the patient, Sacha Tries to keep a secret from Essie, and Ric cracks the whip on the Acute Assessment Unit Floor, But a surprise visitor throws him off his game
Mo finds herself caught between pregnant patient Trixie and Derwoods mother, Oliver's eagerness to impress causes friction between Bernie and Ric, While Sacha revisits his own childhood when his first girlfriend is admitted.
Matteo wants to prove his marriage is over, but a face from the past brings up painful memories of his life before Holby, Meanwhile, Dominic struggles with his first day back.
Jac's job and livelihood are at risk when a mystery patient arrives on Darwin and seeks help, while Keller welcomes a new face to the team. Elsewhere, Oliver has his mind preoccupied with a surprise from Zosia.
Lofty is unexpectedly confronted with his past and realises that he has to come to terms with the life changing choices he has made, while Mo is ecstatic to be offered Jac's job.
As a personal emergency strikes, Mo Makes a heart-wrenching decision, and when Nina oversteps the mark with a patient on AAU, her judgement is called into question.
Dominic and Sacha clash professionally, and with Jac and Jasmine at odds, Fran makes it her business to reunite them - with unsettling consequences, Meanwhile a new arrival on Darwin gets more than they bargained for.
It's crunch time for Mo, who has some difficult life choices to make, and a patient who is dear to Ric forces him to try to mend broken ties. Meanwhile Jasmine has growing suspicious of Fran's intensions with Jac.
As Jasmine begins to investigate the past, She makes a shocking discovery, while a misunderstanding leaves a vulnerable Dom at odds with his new friend Lofty.
Jac buries herself in work, determined to save he life of a scared patient, while Sacha is forced to confront his faith when his mother sets him up on a blind date. Plus, Donna returns
A grieving Morven will not accept the circumstances of a close tragedy, while a familiar face arrives on Keller for emergency surgery, putting Sacha in a compromising position.
Jac and Fran get the shock of their lives when someone from their past turns up at the hospital while Raf realises that he likes Essie more than he's letting on.
Essie worries that she is not being a good foster parent to Parker, and a tricky patient diagnosis throws Morven straight in at the deep end on her first day back.
Donna is dealt a cruel blow by her ex, but assistance is on hand from a surprising source. Elsewhere Dominic wants to uncover the truth about Lofty's life, but he is not ready for what unfolds.
Nina strikes a deal with a face from her past, party animal Morven makes a regretful decision, and Sacha struggles with the new woman in his life.
Bernie is confronted with an impossible situation, Ollie and Zosia are made an offer they cannot refuse, and Lofty has fallen out of favour with Dom.
Guy requests Oliver's help with a patient, hoping to foster support for a new research proposal, Sacha's rabbi is taken seriously ill. Nina questions Matteo's feelings for her.
Oliver struggles with the thought that Tara's death could of been prevented, while Zosia is offered a chance to advance her career. Meanwhile, Lofty worries Dom still has feelings for him.
When events take a tragic turn during the Holby Half Marathon, Lofty is forced to finally confront his feelings for Dom and Fletch must enlist Jac's help to treat a patient.
Hanssen is forced to confront his past when a familiar face arrives as a registrar, and Zosia finally relaxes into some wedding planning, but Guy's behaviour sparks fresh concern.
As Guy's behaviour becomes increasingly erratic, Zosia's concerns put her in an impossible position, and Donna is shocked when her patient has a surprising visitor.
An accident in rehab sets back Fletch's recovery, but it's his attitude that proves the biggest obstacle. Can he beat the doom and gloom before pushing away those who are trying to help him? Isaac wants to impress Ric and Dom wants to impress Isaac, but when Dom sidelines his own success to help make Isaac look good they both wind up in trouble. Mo tries to befriend Inga in light of her new role as best man. Her attempts prove futile when she puts her foot in her mouth repeatedly and winds up covered in wee, having made an enemy out of Inga instead.
Mr T comes to Mo's rescue when she fears for her baby's life. Bernie makes a big decision about her future with Serena when an exciting opportunity arises. A big step in his relationship with Isaac puts Dom's friendship with Zosia at risk.
Dominic is perturbed when Isaac's former surgical mentor is admitted. Despite the existence of a wife, it's clear there's a personal connection between the two men. Is Dom prepared to accept Isaac's past? Jasmine is keen to impress Jac professionally and make a connection with her half-sister personally. But will Jac's public acknowledgement of their relationship bring them together or drive them further apart? Ric is dispatched by Hanssen to deal with the estranged wife of the local MP - the feisty, French Francoise. Will Ric allow himself to succumb to her Gallic charms?
Fletch is recovering from being attacked. Progress stalls when he loses feeling in his feet. As the paralysis spreads, Raf struggles to diagnose the cause. Will he make a breakthrough before it is too late? The passionate courtship of a patient and her beau reminds Zosia what she has lost with Ollie. In the dark about Ollie's relationship with Jasmine, Zosia begins to think about the possibility of reconciliation. A happily engaged patient and her partner present a vision of what might have been for Sacha and Essie. Have they made the right decision in breaking up?
Sacha's birthday celebrations don't go quite according to plan.
With Evie still recovering from her fall, Fletch commits to being a better dad.
Jac returns from her break but gets a shock when she sees who is working on Darwin.
Bernie faces an ethical dilemma when her wayward son arrives at the hospital.
Ric questions his surgical skill when he faces losing another young man.
Ollie questions his worth on the Darwin team.
Essie finds her own life in danger when she tries to help a desperate patient.
Mo struggles with a big choice about her future. Mikey causes more trouble for Fletch.
Jac reaches breaking point when Ollie diverts from her plans.
Dominic comes up with a unique way to grieve the loss of his best friend. Raf and Fletch clash after Raf reveals how he really feels about Naomi.
Cara is feeling vulnerable after the break-up of her marriage as a car crash brings Mo's friend Sorcha and her surrogate son back to Holby.
Cara faces awkward questions following Nicole's disappearance and turns to Jed to help as Mo faces giving William back to Brett.
It is Arthur's first day back at work as he tries to prove that he can cope as Guy's struggle of confidence continues to affect his work.
Bernie starts her first day on the ward trying to put her army life behind her as Arthur's dream of becoming a life donor gets a set back as Serena has to make a decision regarding Jason.
Cara finds herself in a difficult position when Nicole is readmitted to the ward and in labour as Guy tries to cope following the explosion.
Mo heads into work, positively upbeat considering that she will no longer be surrogate mum to William as she is due to give him back to his father. When Brett faces a sudden medical setback and his mother-in-law Viv becomes obstructive, Mo feels she cannot possibly part with her beloved William and decides to abscond with him...
Nicole's return to AAU makes life more difficult for Cara as Dom's delight at being given a difficult case turns bad when dealing with a difficult patient.
Zosia fears that her days on Darwin may be numbered as she tries to impress Jac as Arthur tries to rekindle his friendship with Morven.
Jesse has no choice but to relive some tragic events as he attempts to help the seriously ill sister of a former patient.
Fran steps up her manoeuvres against Jac and after she raises the possibility of a formal complaint from a patient's sister, Hanssen has to take it seriously.
Fran returns to the hospital and takes some drastic action to try and get Jac's attention.
It looks like Serena is going to spend another New Year's Eve alone but after some revellers at a gig are attacked, fate brings more than just a few casualties onto the hospital.
Arthur ends up being pushed to the limit after he attempts to win Morven's affections. Zosia has the chance of a prestigious research internship in Edinburgh and has to tell Ollie.
Hanssen gets ready to fly back to Sweden to see his family and becomes suspicious that Guy is attempting to wrest control of the hospital something which Guy later publicly announces. Serena looks for reassurance that Hanssen will stay and fight the battle.
Back on Keller, Arthur finds himself in a compromising situation by Morven's father as Mo awaits the news if she is pregnant or not.
After an army medic shows up on Darwin Ward, tensions increase for Guy and Ollie. Serena has to make a difficult decision following the discovery of a family secret.
Somebody from from Dominic's past makes an unwelcome return and there are some traumatic consequences.
Cleared by the police, Dom returns to work but Lee still has the power he needs to hurt him as Austin's condition continues to deteriorate.
Arthur's attempt to save the life of a patient after being hit by a train leaves him burying his head in the sand as Adele ends up getting more than she bargained.
Operating on an old school teacher, Ric battles to remain in control as Mo learns that she hasn't won the role of consultant as Serena is worried about introducing Robbie to her family.
Bernie ends up having to question what she wants after her future at the hospital is put in doubt. Ollie and Zosia's world is blown apart after a former flame of his shows up.
Morven is left reeling by a life changing birthday gift as Mo clashes with Sir Dennis over a patient as Ric suffers an emotional outburst.
When Cara makes a move on Raf, complications arise as Arthur receives some shattering news as an old friend of Adele's is admitted to Darwin.
Jason shows up on AAU with his seriously ill carer Allan and Serena’s personal involvement manages to affect her professional judgement as Dom tries to support Arthur following the news that his cancer has spread as Cara has her first day on Darwin.
Bernie finds herself being served with divorce papers as Austin is admitted in urgent need of a transplant as Zosia persuades a dying patient to act as a guinea pig.
The arrival of her ex sees Bernie trying to keep her secret hidden as the hospital's new psychiatrist Naomi Palmer makes an instant impression on Fletch.
Mo finds herself having to listen to her heart instead of her head as Serena's actions leave devastating consequences as Arthur and Morven have a day they won't forget.
Zosia manages to overstep the mark and accuses a patient of a media leak forcing Oliver to deal with an unwelcome dilemma. Zosia comes to a gut-wrenching decision as Serena discovers Bernie is working on AAU, Dominic has to face his fears.
Arthur is determined to proof himself with Hanssen's ambitions as Raf manages to see Naomi in a different light as Oliver tries to get back together with Zosia.
Zosia finds herself having to chose between Arthur and her career as Dom finds his loyalty being tested by a familiar face as Bernie finds it hard to find her place on AAU.
Zosia begins to question where her loyalties lie as Arthur and Morven have a decision to make as Dom battles his guilt.
A major train accident sees Dom with the perfect opportunity to escape back into work mode. Bernie’s husband attempts to to play dirty in the divorce, as he turns her children against her.
As Jac launches the fully-formed Digby Stent, it looks like that someone has stolen their patent. Dom’s first day back doesn’t go as planned after a forthright new registrar shakes up the ward.
Guy's career continues to go from strength to strength but there is a cost. Essie lets her personal life affect her professional one as she attempts to deal with a difficult mother and son relationship.
Following the death of his mother, Jesse attempts to reappraise his relationship with his father as Ina is readmitted to Darwin.
Guy must face his past when an unexpected patient arrives at Holby.
Bernie has to work alongside an old army colleague and ends up being forced to confront the secrets of the past and face the truth behind her sudden exit from the army as Mr T learns that no one takes him seriously as Serena has a choice to make between her happiness and Jason.
When Elliot's first love tumbles back into his life, Elliot makes a startling choice.
Cara is shell-shocked when her undercover cop husband arrives at the hospital.
It's the day of the wedding. Adele's world is rocked when she makes a startling discovery.
Dominic's past returns to haunt him. Mo needs a date for her sister's wedding.
Jac considers the possibility of a new start with Emma in the USA.
Is Sacha prepared to sacrifice the love of his daughter and do the right thing?
Dominic and Arthur compete to impress, but are they stronger together than apart?
Serena is distraught when her mother does not recognise her.
Guy is forced to confront the fact that Zosia may not be cured of her mental illness.