The NCIS's New Orleans field office investigates criminal cases affecting military personnel in The Big Easy, a city known for its music, entertainment and decadence. Leading the team is Special Agent Dwayne 'King' Pride, a native of New Orleans who is driven by his need to do what is right. Working with him is Special Agent Christopher LaSalle, who plays hard but works harder; and Special Agent Meredith 'Merri' Brody, a charismatic and tough interrogator who transferred from the Great Lakes office in search of a fresh start. Supporting them is coroner, Dr. Loretta Wade, who is as eccentric as she is smart. This colorful city that harbors a dark side is a magnet for service personnel on leave, and when overindulgence is followed by trouble, Pride's team is at its best.
While Pride remains on probation six weeks after his rogue takedown of the corrupt Mayor Hamilton, his team is closely monitored by Supervisory Special Agent Paula Boyd. Also, when the FBI arrives to run lead on a case involving a stolen big rig of nuclear waste, the team must secretly investigate from the sidelines.
After a sailor is murdered in the champagne room of a strip club, the NCIS team links the murder weapon to two additional unsolved cases and discovers that the names of all three victims appear on a mural in a dilapidated part of town. Also, Brody’s ex-fiancé pays her a surprise visit.
While conducting an autopsy on a Petty Officer who is believed to have died from natural causes, an armed man enters the morgue and holds Wade, Sebastian and Danny hostage.
With no memory of the night before, Lasalle’s brother, Cade, turns to NCIS for help when he finds his girlfriend’s body in the trunk of his car. Despite a mountain of evidence that implicates Cade, and the case being under Captain Jim Messier and Jefferson Parish jurisdiction, Lasalle is determined to prove his brother’s innocence.
To send a message to Pride, Baitfish murders someone close to the NCIS team, prompting a citywide manhunt for the elusive criminal.
Pride suspects a mole among the ranks as NCIS and local law enforcement continue to track the Broussard Syndicate after new intelligence suggests a breach at the ports.
Pride is adamant the elusive “Baitfish” has returned and, in attempt to locate his nemesis, he has the team investigate crime scenes and chase leads from New Orleans to Charleston, SC.
A case involving the murder of a petty officer, who is a former gang member and later mentored by agent Pride, is investigated. Meanwhile, agent Brody is still trying to get acquainted with New Orleans and doctor Donald "Ducky" Mallard also offers some insight.
NCIS Special Agent Tony DiNozzo assists the New Orleans team when a Navy lieutenant on liberty dies of the bubonic plague. The team races to locate all additional sailors on liberty, control a potential outbreak and determine the source of the highly infectious disease. NCIS stars Michael Weatherly, Rocky Carroll and Pauley Perrette guest star.
The NCIS team investigates the crash of an armored transport bus carrying Naval brig detainees after four prisoners escape, including a black market broker who is one of the country's biggest national security threats. Meanwhile, Pride turns to Gibbs for assistance when a case file needed for the investigation is full of redactions. NCIS stars Mark Harmon and Rocky Carroll guest star.
After a Navy SEAL is found murdered in a sorority house, the NCIS team must determine if the motive pertained to one of his classified missions or collegiate foul play. Meanwhile, Pride's daughter, Laurel, pays the NCIS office a visit. Shanley Caswell stars as Pride's daughter, Laurel.
The NCIS team is given a 22-hour deadline after the murder investigation of a Chief Warrant Officer who specialized in counterintelligence reveals his wife had been kidnapped and is being held for ransom. Meanwhile, Senior FBI Agent Fornell travels to the Big Easy to assist with the case. NCIS stars, Rocky Carroll and Joe Spano, guest star.
With New Orleans decorated for Halloween, the NCIS team investigates the murder of a Naval Staff Judge Advocate found in a cemetery dressed in a Victorian costume with vampiric puncture wounds on her neck. Meanwhile, the team debates what Halloween night activity and costumes would be best. Paige Turco and Steven Weber guest star.
The NCIS team investigates the murder of a Navy Officer with the highest level top secret clearance who was recently assigned as a tech liaison with a private developer. Also, Pride transforms the carport into an auto shop as he works on the first car he ever gave his wife.
The NCIS team investigates the murder of a Petty Officer found in a Mardi Gras float storage facility with an engagement ring and proposal plan in hand. However, the case takes a mysterious turn when the team is unable to locate his supposed long-term girlfriend.
After a stolen Navy-issued gun is found to belong to a Chief Petty Officer who died 40 years ago, the NCIS team reopens the cold case, one that Wade has personally tracked and investigated for years. Also, the team prepares for their annual Thanksgiving dinner together. Steven Weber and Dean Stockwell guest star.
The NCIS team investigates the murder of a retired SEAL who tracked down individuals impersonating military personnel. But the case takes a mysterious turn when the lead suspect is found with the Navy-issued jacket of an officer believed to have been killed in the line of duty in Afghanistan. Also, Brody discovers the normally holiday-obsessed Lasalle is inexplicably unenthusiastic about Christmas.
The NCIS team investigates a deadly explosion at the Navy-Marine Corps Relief Gala, and discover Pride (Scott Bakula) was the intended target of the bomb.
When a Navy Admiral’s daughter is the prime suspect in a double murder case aboard a research boat, the NCIS team partners with the Coast Guard Investigative Service (CGIS) to work the case. Meanwhile, Lasalle tracks down his estranged brother.
A Navy Lieutenant Commander in impeccable shape turns to Pride and the NCIS team to solve his imminent murder after discovering he has been poisoned with a lethal dose of radiation.
After an NCIS agent is killed during a security detail for the Vice Chief of Naval Operations, the team must determine if this was an assassination attempt or if someone is targeting one of their own. Meanwhile, Agent Brody is placed under investigation and her mysterious past is reevaluated.
After a Petty Officer is found murdered in the midst of Mardi Gras events, the NCIS team investigates what parades and parties led to his untimely death. Also, Pride must decide what aspects of his strained relationship with his father he is willing to share with his daughter.
After a Navy recruiter is the target of a lethal hit and run, the NCIS team investigates whether the murder was tied to her career or her role as a foster mother to two brothers. Also, Lasalle grows increasingly concerned for his brother’s welfare after welcoming him into his home.
When a Navy Commander’s car is stolen with his baby inside, the NCIS team must determine if this was a random carjacking or a targeted abduction.
The NCIS team partners with several federal agencies to track a sniper who is targeting crowded events in the city. Also, FBI Special Agent Tammy Gregorio arrives to investigate Pride and his team.
Pride faces further backlash from the FBI when he helps former Navy Intelligence Analyst Elvis Bertrand, who is the lead suspect in a multiple homicide case.
After a decorated petty officer is found dead inside a sports arena, evidence leads Pride and the NCIS team to a kidnapping case of a petty officer who was last seen in Mexico.
The NCIS team must rescue one of their own after Sebastian is kidnapped while at a restaurant with his mother, Sylvia Lund, and forced to use his gaming skills in a prison break.
The team join forces with the FBI to investigate a plane crash in the bayou that left three sailors dead. Meanwhile, Sonja and Lasalle interview candidates for the open agent position.
The NCIS team reviews unorthodox training exercises after a Navy Seal candidate is found murdered weeks before his graduation. Also, a concerned Wade turns to Pride after her adopted son, Danny, announces his plan to enter the Navy.
The NCIS team investigates the murder of a sailor during a rowdy motorcycle rally in the city. Also, Lasalle turns to Gregorio for advice on his personal life.
After a petty officer and member of the prestigious United States Navy Band is murdered in her home, Pride takes temporary custody of the victim’s nephew who is the sole witness to the crime.
The team suspect foul play when a Marine corporal and amateur race-car driver is involved in a fatal crash. Elsewhere, the U.S. Attorney's office gathers evidence for a Grand Jury indictment appeal in the Garcia case that would extricate the cartel from the city.
Pride must protect a beloved family friend who is engaged to the number one suspect in the ongoing NCIS and FBI cartel case.
Sebastian is sent undercover and Patton exercises his former gambling skills, as Pride and the team attempt a dangerous operation to trap Garcia.
After Pride travels to a deep sea oil rig for a murder investigation, the team uncovers a gas leak that's on the verge of causing a catastrophic explosion. Also, Sebastian starts his NCIS special agent training at FLETEC.
After thousands of classified government files are stolen, the NCIS team searches for an underground group of hackers co-founded by Pride’s old contact, Elvis Bertrand, who are known for exposing corruption among prominent people in New Orleans. Also, Sebastian joins the team as a newly minted NCIS Special Agent.
NCIS agents McGee and Torres travel to New Orleans to partner with Pride and his team in the search for a missing homeland security theoretical terror playbook. Crossover with NCIS season 14 episode 15
A gruesome copycat murder on a street car reopens a former case for Wade, evoking painful memories from her past.
Pride’s longtime friend, state and military attorney Rita Devereaux, asks NCIS to investigate the disappearance of a JAG lawyer who specializes in classified cases and volunteers at a private military academy.
While investigating a deadly accident at a naval base, NCIS discovers a unit of Seabees was poisoned with a contagious super virus leaving the rest of the base and the entire city of New Orleans at risk for a catastrophic outbreak. Also, during the autopsy, Wade is infected with the virus and given hours to live if an antidote can’t be found.
After the NCIS team uncovers a link between an international drug ring and the New Orleans Police Department, Lasalle must investigate his former partner in the Vice unit. Also, Pride worries about Rita’s safety as she looks into a connection between the Mayor and illegal activity in Clearwater.
While Pride listens in on a wiretap of Mayor Hamilton, the NCIS team investigates a train heist of hundreds of Navy weapons,
After the Belle Chase Navy Chaplain and pastor at Clearwater Baptist is murdered, Pride believes he found a connection between Mayor Hamilton and the illegal activity taking place in the city of Clearwater. Also, Percy continues to face repercussions of her choices on a previous case.
After Pride is spotted tracking one of Mayor Hamilton’s accomplices, the suspect opens fire on a crowded street before disappearing.
Unable to trust anyone in New Orleans, the NCIS team calls in FBI Assistant Director Isler to help expose and stop the sinister scheme Mayor Hamilton has planned for the residents of Clearwater. Season Finale.
A military convoy is attacked in order to steal a missile that is part of a Naval exercise. Pride and the team, believing that it is perpetrated by a group of anti-American militants, make plans for a dangerous undercover operation with potentially deadly consequences.
When a female combat pilot and Navy hero dies in an air-show plane crash, the NCIS team must investigate if it’s the fault of the pilot or the new jet that was just approved to deploy to bases globally.
The NCIS team must determine why a murdered Navy drone pilot was using a black market drone to obtain military surveillance, and whether the drone’s footage is linked to his death.
Special Agent Pride is sent a partner from the Australian Defence Force Investigation Service, Special Agent Naomi Parsons, after a Royal Australian Navy Lieutenant, who was key to international negotiations on nuclear weapons, is murdered in New Orleans.
The team’s participation in the annual Red Dress Run is cut short when a Petty Officer is found dead in the French Quarter from a drug overdose.
The life of a genius Navy coder employed by Brody’s mother, Olivia Brody, hangs in the balance after the heart intended for his transplant is stolen. Olivia joins the NCIS team as they race to locate the missing organ.
Pride and Sonja are ambushed after traveling to Texas to escort a key witness for the trial of an infamous arms dealer who Pride apprehended.
The fiancé of Pride's daughter's friend goes missing during a blackout; and the team locates the man's dead body, which holds clues to the cause of the blackout.
The murder of a Marine provides new clues in the first case Pride and Lasalle ever worked together, just before Hurricane Katrina struck the city and washed away any evidence. Also, the team celebrates Thanksgiving together in Pride’s bar.
A string of Christmas burglaries turns deadly and the evidence leads the NCIS team to Wade’s adopted son, Danny. Also, Lasalle and Brody tease Sonja about the high stakes of drawing Pride in the team’s Secret Santa holiday exchange.
The team investigates the murder of an immigrant petty officer that was staged as a suicide. Also, the agents secretly create an online dating profile for Pride.
Special Agent Pride opens his bar to the public with a Fat Tuesday party, but the celebration is cut short when he and Mayor Douglas Hamilton (Steven Weber) are both kidnapped from their respective Mardi Gras events and held hostage by an unknown assailant.
When a mystery man saves the life of a Lieutenant and then disappears from the scene, the NCIS team unravels a new case when forensic evidence suggests he is a soldier who was captured in Afghanistan years ago and never found.
After tracking stolen Navy TNT to a cocaine warehouse, Special Agent Pride and the NCIS team uncovers a domestic drug ring that is producing their own cocaine and headed by Sonja’s childhood friend, Marion Watkins.
The NCIS team protects a local DJ from a threatening perpetrator and investigates the murder of a Navy Captain who was attacked while on-air with the radio show. Also, Pride’s daughter, Laurel, returns home to discuss her future plans.
Brody believes that a sailor hit by a party bus in the French Quarter is connected to her sister’s death after the NCIS team discovers similarities between the two. The team prepares for St. Patrick’s Day festivities in New Orleans.
The NCIS team discovers a surveillance van filled with photos documenting Special Agent Pride’s every move after his daughter Laurel is attacked on campus and placed in protective custody.
The NCIS team investigates the murder of a Navy Lieutenant during a French Quarter second line funeral procession, a New Orleans tradition that celebrates the recently deceased with a musical street parade.
After a Navy lieutenant dies during a clandestine visit to a general’s hotel room, Special Agent Pride and the NCIS team are asked to break standard protocol for the murder investigation.
A Navy culinary specialist is the target of an explosion while visiting her family’s 100-year-old restaurant in the French Quarter. Also, Brody is in D.C. tracking a lead in the General leak case.
The team partners with Homeland Security for the investigation of a Navy master diver's murder after learning the death could be linked to a foreign attack on the city.
The NCIS team uncovers a mole in the ranks while working with the Department of Homeland Security to locate 900 missing pounds of explosives that pose an imminent threat to New Orleans.