The series follows Paige and Frankie who write funny songs and create music comedy videos for their online channel, "Bizaardvark." Now with 10,000 subscribers, they are invited to produce their videos at the influential Vuuugle Studios. In this cool environment – and with the help of longtime friend and 12-year-old agent Bernie, plus fellow Vuuugle stars Dirk and Amelia – the best friends embark on comedic adventures in their quest to rule the blogosphere.
Amelia Convinces Paige and Frankie to create a Draw My Life video, Telling one another to be more interesting which leads to a Competition; Bernie tries to help Dirk overcome his fear to complete a dare involving snapping turtles.
When the girls receive mean comments about their videos, Frankie begins to lose her confidence and becomes obsessed with finding who wrote them.
Paige and Frankie feel like they’ve officially “made it” when they discover that they have their very first superfan, Belissa!
Frankie and Paige try to boost their subscriber level by collaborating with popular Vuuugle stars Victor of “Prank Town” and JiffPom.
When Paige convinces Dirk to stop doing such risky dares, his brother Kirk is worried the dare-devil is broken for good. Meanwhile, Bernie & Frankie try to find an office space to call his own for an important meeting.
Paige and Frankie are suspicious about Amelia having an actual best friend named Becky who she claims travels the world. So Paige and Frankie invite Amelia over for a sleepover where Amelia's antics annoy Paige and Frankie. Meanwhile, a dare involving a bowling ball return causes Dirk and Bernie to accidentally destroy the robotic monitor that Liam speaks through as they work to dispose of it before someone finds out that they "killed" Liam.
Liam suspends Paige and Frankie from Vuuugle's studio for two weeks when he finds out that they plan to have pyrotechnics in their latest video. Bernie convinces Liam to take a vacation and leave him in charge. While Liam is away, Bernie actually listens to the other Vuuugler's issues which Liam never deals with. Meanwhile, Amelia enlists Marge to help her with Gliiink, a one second video app.
The beauty convention Pretty Con has come to Vuuugle and is being hosted by Meredith Foster. Due to Angelo resigning in order to finish med school and work in doctor-less countries, Paige and Frankie work with Amelia in exchange for showing the latest Bizaardvark video if she wins. Amelia ends up in a competition with a nine-year-old beauty guru named Didi. Meanwhile, Bernie goes through the initiations in order to attend Dirk's Dude Con.
Bernie is still trying to get some other Vuuuglers to let him be his agent with no success. At the suggestion of Paige and Frankie, Bernie starts to meet with different Internet animal stars until he manages to land some cats and does some cat-themed videos mixed with some Bizaardvark songs which lands him on a spot for Britt Pickle's upcoming series at Vuuugle. Meanwhile, Belissa returns where she is interning at Vuuugle as Amelia tries to get Belissa to subscribe to Amelia's page.
The v-loggers have to make a scary Halloween video for Vuuugle’s homepage, but they can’t decide whose video is the scariest – Frankie and Paige’s tale of the ghost of Hollander Prep, Dirk’s haunting world without dares, or Amelia’s zombie apocalypse.
When Paige and Frankie have a hard time trying to write a song for Bizaardvark, Frankie accidentally wishes for bad things to happen to them. Still interning at Vuuugle, Belissa overhears this and "helps" them out where she steals Paige's phone, drops water on Paige's electric guitar and on Frankie's keyboard, tries to drop a studio light on Frankie, and later frames the girls for breaking inside the mayor's house. Meanwhile, Dirk and Amelia try to find Dirk's lucky bandage after it went missing when Amelia did an ambush reorganizing in Dirk's area.
When Paige and Frankie learn Vuuglers get into feuds for publicity or subscribers, they decide to start a fake feud with 13-year-old MMA fighter Vicki “Thunder Foot” Fuego; however, their idea doesn’t go according to plan.
When the girls realize that the most popular videos on the internet don’t require much thought, they decide to make a silly video of their own about a moose named “Moosetashio.”
A rich Bizaardvark fan invites Paige and Frankie to his mansion and helps pay for their expensive video idea, however, the nice gesture takes an unexpected turn and the duo come face to face with social media star Eva Gutowski.
Bernie goes on social media star Rosanna Pansino's baking show to try and get 10,000 subscribers to fulfill his dream of being invited to the Vuuugle holiday party, along with his buddies, Paige, Frankie, Dirk and Amelia. Meanwhile, Dirk is on a mission to find the perfect gift for Horse Face.
Paige has mixed feelings when her mom hires her and Frankie to sing while they wait tables at their family restaurant. Meanwhile, Dirk gets himself trapped in his lair in an avalanche of props.
Frankie goes to extreme lengths to throw Paige the best birthday party ever, including tricking social media star Lilly Singh to attend the party.
Paige and Frankie, along with fellow Vuuglers Victor and Dirk, are picked to participate in a popular web series reality competition called "In Your Space!" Meanwhile, Bernie tries to impress Amelia with his suave moves.
Paige, Frankie, Bernie, and Amelia begin their first day of high school. Paige and Frankie are disappointed when they learn that they will not have any classes together, but they decide to make the best of the situation and try to work through it. While Paige enjoys the new school and immediately makes several new friends, Frankie believes that she does not fit in after having a bad first day, as she has difficulty making new friends and keeps getting her hair caught in her locker. Paige cheers Frankie up and convinces her that it will take time before she fits in and makes new friends. Frankie becomes happy when several students recognize her and Paige from Bizaardvark. Meanwhile, Amelia realizes that her teacher and none of her classmates like her except for Bernie, who cheers her up. Dirk returns to the high school to perform a dare in which he uses rocket-powered leaf blowers to propel him through a wall. In the post-credits, Paige cuts Frankie's hair as they do their latest video about their first day of school.
Paige and Frankie film a video for Bizaardvark in which they are dressed as chocolate bananas while singing a song. When they begin editing the video, they realize that their costumes actually resemble feces and decide not to publish the video. The next day, graffiti is discovered on some of the school's lockers. Paige and Frankie realize that they caught the suspect in the background on their video, but they are hesitant to show the embarrassing tape to Principal Karen. More graffiti appears the next day, and Amelia becomes the suspect after a security guard spotted her leaving school the night before. After Amelia receives detention, Paige and Frankie plan to secretly create new graffiti during a school event that she will be attending, in order to demonstrate that she is not the vandal. However, Paige and Frankie are caught with spray paint and are brought into Principal Karen's office. The real culprit Simon Vandalman is caught by Security Guard Clark before Paige and Frankie hand over their video to Karen, but the footage is taken anyways as possible evidence, leading to the video being aired on a news program. Meanwhile, Bernie considers Dirk to be his best friend and says so to him, but he is upset when Dirk does not repeat it back.
Dr. Wong, Frankie's father who works as a medical doctor, takes two weeks off from work so he can spend more time with her. Frankie neglects an upcoming test and term paper so she can spend time with her father, who began working more often after divorcing her mother so he could afford to provide Frankie with whatever she wanted. When Frankie becomes stressed out about not getting her homework finished on time, she tells her father, who decides to work less often from now on so they can spend more time together. Meanwhile, when Dirk becomes tired of Vuuugle's hot chocolate bar, a group of Vuuuglers unite with him to have it torn out for something better. The group rejects Amelia's idea to replace the hot chocolate bar with a beverage bar that would offer a variety of drinks. Dirk is unable to think of a concept worthy of replacing the hot chocolate bar, which he then unsuccessfully tries to put back together. Liam then has the space converted into a first-floor office for himself so that Viking Guy no longer has to carry his mobile monitor up the stairs, while Dirk and the other Vuuuglers set up a dart board outside the new office for their enjoyment.
Paige goes on a date with a boy she likes named Reese, who requests that she not make him the subject of any Bizaardvark videos; Paige assures him that she does not plan to do so, but Frankie encourages her to keep the possibility open. During a date, Reese reveals to Paige that he has a caterpillar named Roger, which inspires her and Frankie with numerous video ideas. Frankie convinces Paige to proceed with the videos and end the relationship with Reese. When Frankie realizes how much Reese likes Paige, she tells her to get back together with him. When Paige reveals to Reese her idea for a Bizaardvark video about his caterpillar, he approves of it and later appears in the video. Meanwhile, Bernie joins the school wrestling team and obtains a wrestling jacket, which gains him attention from girls, including an invitation from Amelia to a party she is having. Bernie is initially the only child in his weight class, but when Coach Carlson discovers that Bernie has gained weight, he is put in a wrestling match against a boy known as The Brick. After Bernie loses the match, his jacket is revoked and he is disinvited to the party. In the post-credits, Paige and Reese do their video with Frankie portraying Reese's caterpillar.
Paige and Frankie are given a Vuuugle studio after Bizaardvark reaches 100,000 subscribers. However, they disagree on how to decorate the new studio. Frankie wants Paige and herself to decorate the studio, while Paige wants to let their fans decide how to decorate it. Their disagreement escalates when Frankie accuses Paige of being insecure and worrying about what other people think of her. Frankie, who is not insecure, later tells Paige that she has tried not to care about what other people think after her mother left the family. Paige and Frankie rekindle their friendship and decorate the studio themselves. Meanwhile, Amelia agrees to dance in a school fundraising event so she can become friends with the event's organizer, Rachel. However, Amelia does not know how to dance, so Bernie offers to teach her. Bernie also does not know how to dance, but learns from his grandmother by dancing with her. During practice, Bernie realizes that his grandmother only taught him how to perform dance moves meant for the role of a female dance partner, such as the dip. Instead, Amelia and Bernie decide to perform their own dance moves, but their performance is poorly received. In the post-credits, Paige and Frankie give the viewers a tour of their studio.
Paige is upset to see that the school mascot, an owl named Hawk, is confined to a cage. Paige secretly brings the owl to Frankie's house so she can eventually set it free, but then the girls learn that the animal will not be able to survive in the wild because it has no survival skills. Principal Karen locates the owl, and Paige confesses to taking it. Principal Karen tells them that Hawk is only put in a cage during school events, and that it otherwise lives at a 100-acre nature sanctuary. As punishment for their actions, the girls are required to take Principal Karen's six-hour owl safety seminar, and must pay a fine and perform community service. Meanwhile, Dirk has agreed to watch his friend's eight-year-old brother Patrick who enjoys destroying things. Amelia and her friend, Alisha Marie, have created a shower chandelier which is meant to hang above a shower and dispense soap and shampoo. Patrick convinces Dirk and Bernie that he is actually an undercover CIA agent who has been tasked with destroying the shower chandelier because it poses a national security risk. Patrick eventually succeeds in destroying the shower chandelier much to the dismay of Amelia and Alisha.
Bernie's grandmother decides to take Paige and Dirk camping so Bernie can demonstrate the skills he learned from a camp school. However, Bernie secretly tells Dirk that he did not attend camp school, choosing instead to play a dancing arcade game at Vuuugle during each day that the camp was held. Bernie pretends to have camping skills, but eventually tells his grandmother the truth. Meanwhile, Frankie and Amelia decline to go on the trip as they do not like camping. Frankie and Amelia decide to become closer friends, and learn that they both share an interest in winning a hot-wing-eating contest at a restaurant. However, after winning the contest, they struggle to think of any other interests that they share. When a raccoon enters Frankie's house, the two girls wind up camping outside to stay away from the animal.
When Frankie's father, Douglas, decides to start dating, she and Paige take him to a school meeting, hoping that he will meet a single woman there. The girls are surprised when Douglas takes an interest in their teacher, Ms. Dana Bates. The two begin dating, which discomforts Frankie, as she begins having delusions that the cool children at school are mocking her because of her father's new relationship. Frankie and Paige look through Dana's office, hoping to find something that will make Douglas want to end the relationship. The girls then overhear Dana during a phone conversation and believe that she is cheating on Douglas with a man named Max. Paige and Frankie confront Dana at a restaurant, where they learn that Max is actually her son. Frankie later approves of the relationship when she sees how happy Douglas and Dana are. Meanwhile, Dirk's back is hurting after two months of sleeping on the floor at Bernie's house, so the two decide to buy a bunk bed designed to look like a yacht. However, they lack the money needed to purchase the bed, and their request for a bank loan is rejected. Out of anger, Dirk punches a hole in the wall at the DareMeBro studio, and Bernie notices money inside the wall. Dirk explains that he uses the money as insulation. When Bernie attempts to punch a hole into the wall to retrieve more money, he breaks all the bones in his arm and the money is spent on medical treatment for him.
Paige and Frankie have Dirk join the Vuuugle softball team, but they are disappointed to discover that he does not play well. To avoid hurting Dirk's feelings, Paige and Frankie tell him that the upcoming softball game was cancelled. However, Dirk sees the team return to Vuuugle from the game while they are still wearing their softball uniforms. The team devises a cover story by telling Dirk that they were rehearsing for a Vuuugle musical titled Softball: The Musical. Dirk intends to see the show, forcing the softball team to put a real musical together, but he later announces that he now has plans to attend a wedding on the day of the show. Viking Guy, an unintelligent member of the softball team, tells Dirk that the musical can be rescheduled so Dirk can attend, thus forcing the team to continue with the show. Amelia invites her subscribers to see the musical. After the musical concludes, Viking Guy tells Dirk that it was only put on to avoid telling him the truth about his lack of softball skills. Paige and Frankie apologize to Dirk, and promise to be truthful from there on.
Paige and Frankie have a disagreement about what their next video should be, with Frankie saying no to each suggestion that Paige makes. Paige points this out to Frankie, who notes that Paige usually says yes to things. They make a bet in which Paige can only say no when asked questions, while Frankie can only say yes. The winner gets to choose how to spend their collection of arcade tickets. Paige realizes how relaxing her life can be when she says no to people, as she has more time for herself. Bernie introduces Gaby, a young girl, to Paige. Bernie says Gaby has traveled from Fiji to hear Paige sing, but Paige rejects her request as part of the bet. Paige then learns that Gaby was hired by Frankie in an attempt to make Paige lose the bet. Paige meets an unsanitary student named Marlene, who is in search of a school mentor. Paige tells Marlene to ask Frankie to be her mentor, and Frankie reluctantly accepts the request to avoid losing the bet. When Frankie tells Paige how tired she is of Marlene, Paige offers to spend some time with Marlene to give Frankie a break from her. Paige loses the bet when says yes during their conversation. Frankie had intended to get a fighting robot with the tickets, but she does not have enough tickets and instead settles for thousands of spider rings. Meanwhile, Amelia learns that her Vuuugle channel could gain new subscribers by posting outtakes of herself. However, she has never made a mistake during her videos, so Dirk and Bernie help her.
Frankie babysits her neighbor, a girl named Savannah, who is working on a science fair project about crickets. After learning that one of Savannah's classmates is getting help from his parents on his science fair project, Paige and Frankie are reminded of an earlier science project that they worked on, which lost to a boy whose project also received help from his parents. Paige and Frankie decide to help Savannah with her project, to avoid a repeat of what happened to them. Paige and Frankie have a Vuuugle science channel build a functioning satellite as Savannah's project, which they believe will easily win the contest. At the science fair, Savannah tells Paige and Frankie that she does not care about winning. Instead, Savannah presents her cricket project with help from Paige and Frankie, who portray the roles of cricket puppets. Meanwhile, Bernie is told by Liam that he must do a presentation for Bizaardvark so it can remain a Vuuugle channel. However, Bernie is occupied with thoughts of his presentation, and inadvertently ignores Liam's instructions on how it should be done. Bernie later gives his presentation and hopes for it to be adequate. Liam, busy fantasizing about quitting his job, inadvertently ignores the presentation but allows Bizaardvark to remain at Vuuugle.
Paige and Frankie help their fellow students to ask people out for prom by putting together elaborate prom proposals known as promposals. Paige and Frankie have successfully helped nine children get dates for the prom, but they are worried about disrupting their winning streak when Bernie asks them if they can get him a date with Kate, a tall tennis player who is an honor roll student and the president of her class. Paige and Frankie do not believe Kate would want to go to prom with Bernie, so they have Amelia ask him instead to spare him of public rejection. After Bernie learns the truth, Paige and Frankie decide to proceed with a promposal for Kate. Bernie eventually gets a date with Kate on his own, but because of his clumsiness, he inadvertently disrupts the prom and hurts Kate. Meanwhile, Dirk tries to avoid hearing spoilers about the season finale of a television series until he can watch it with his brother. However, Amelia and Viking Guy repeatedly discuss the finale while Dirk is around. After Dirk watches the finale, he learns that Amelia and Viking Guy are no longer interested in discussing it as they have begun watching a new television series.
Paige, Frankie, and their friends decide to tell Halloween stories after the power goes out at Vuuugle. In Paige and Frankie's story, Bernie visits a store that is operated by a witch who resembles Amelia. As a present for Paige and Frankie, Bernie purchases cursed dolls that resemble the girls. The dolls come to life and create their own Vuuugle web show, with plans to become more popular than Bizaardvark. Paige and Frankie destroy the dolls and eat them, not realizing that consuming them will turn the girls into dolls. In Dirk's story, he is dared to spend Halloween night at his Vuuugle studio. Dirk and Bernie visit the witch's store to buy him a coffin to sleep in. The morning after the dare, Dirk awakens as a vampire and later convinces Amelia, Bernie and Viking Guy to let him turn them into vampires. In Bernie's story, he purchases a cursed cologne from the witch and is transformed into a werewolf at school, where he becomes popular among the students. Paige, Frankie, Amelia and Dirk express disappointment with Bernie's story, leading him to expand it with further details that he adds in as the story progresses.
The Bizaardvark girls and their friends are enjoying the holiday party at the Vuuugle building, until an evil army of killer robots crash the festivities.
Paige and Frankie turn to crazy Biaardvark Superfan Belissa to learn how to combat Principal Karen's over the top obsession with the duo.
Dirk undergoes a crisis as to the direction of Dare Me Bro! Paige and Frankie struggle to stay awake with the new somnolent science teacher.
When Bernie becomes fed up with his grandmother treating him like a baby, he decides to move out and stay with Frankie.
When Paige’s childhood best friend Izzy comes to town, Paige becomes envious of how well Frankie and Izzy hit it off and starts to feel like the third wheel.
When Frankie declares a girl at their school, Jade, is a bad person, Paige sets out to prove her wrong.
Paige and Frankie kick off spring break creating a variety of fun videos with their buddies and other fan-favorite video bloggers.