Ruthless politician Mayor Tom Kane (Kelsey Grammer) sits like a spider at the center of Chicago's web of power. But underneath it all, Kane hides a crushing secret. His trusted advisors Kitty O'Neill (Kathleen Robertson) and Ezra Stone (Martin Donovan) know better than to ask questions. Kane's wife Meredith (Connie Nielson) knows nothing. Only Emma (Hannah Ware), Kane's estranged daughter, has a chance of uncovering the truth. This is going to be the toughest term yet for the Boss.
Tom Kane cements his mayoral legacy with a lavish ceremony celebrating the groundbreaking of the new modernized O'Hare terminals. Now Kane looks to the future, setting his sights on reviving a subsidized housing project. While his political future seems bright, Kane continues to battle for control over his disease.
Kane uses personal tragedy to further his agenda, poaches his nemesis's aide, Mona, and hires ambitious newcomer Ian - but will they be enough to fill the void that Stone left behind?
Kane's increasing infatuation with his new aide Mona leads him to get swept up in her enthusiasm for a housing-redevelopment project.
Kane attempts to clean house and deep-sixes longtime political cronies, while at home, Meredith and Emma want no part of a family reunion with him.
Kane's corruption sweep threatens his political hold over the City Council. His mental symptoms begin to spiral out of control - Kane can no longer tell what is a hallucination and what is reality.
Kane's moves with the housing project escalate tensions from unrest to rioting and looting. As Chicago burns, Kane secretly seeks treatment at an alternative clinic, where his past haunts him.
Kane's alternative treatment seems to have worked and he is back in control of his city. Now he must remedy his public perception, even if it means making an old friend collateral damage.
Kane reluctantly enters an alliance with a longtime foe on City Council, but he soon realizes that more serious measures must be undertaken to stave off bankruptcy.
Chicago's bankruptcy crisis means a loss of power for Kane as emergency measures are put in place, but threats by his enemies to expose him could be of even greater concern.
Miller publishes a story that could destroy Kane, but Kane's biggest threat is Kitty's alliance with Doyle. As Meredith forms a new relationship, Kane goes to the greatest lengths yet to stay on top.
After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.
With a new, powerful entry in the race, Kane and his people flex their political muscles to maintain their hold. Meanwhile, a worried Meredith suspects her husband is keeping something from her.
With Zajac's campaign gathering steam, Kane needs to adjust to his health situation; Miller digs deep to come up with some embarrassing dirt on Gov. Cullen.
Kane finds himself starting to lose control, both politically and personally, as his supporters begin to question their confidence in him. Zajac ventures into uncharted territory while campaigning as Miller continues to dig for answers.
After long-buried information resurfaces, Kane and his camp find themselves battling the media for control of public perception. With the primary just around the corner, they'll have to pull out all the stops to contain the situation and keep the upper hand.
Kane takes an unannounced break from City Hall as his political image hits an all-time low. The election looms and he'll need to enlist the help of others to weather this storm. Kitty, at an emotional impasse, makes a bold move while Meredith, increasingly suspect of Kane's behavior, seeks opportunities of her own.
Just days away from the election, Kane slowly regains control over City Hall. Though a swift political move will help identify his adversaries, will doing the unthinkable improve his public image in time?
Election Day. The race is close, and while the candidates campaign, Kane and Stone must do their part to turn the gears of the political machine. Emma's world is turned upside-down while Meredith must go to great lengths to prove her allegiance to Kane.