An animated sketch-comedy show, Sclopio Peepio comprises short, singular routines, short films, and songs. Each episode is a quarter-hour long, with some sketches lasting only a few seconds.As part of the main cast, Affion Crockett, Ilana Glazer, Darrell Hammond, Gabourey Sidibe, and Neely provide the voices of various characters. One guest star appears each episode.
Special guest star Mary Elizabeth Winstead. Sketches include: Cute Corner, Doo-Doo Man, Li'l Perf, The Most Real Man in the World, Swamp Hag, Donald Sutherland Flavor Potato Chips and Fruit Blood: Cocks.
Special guest star Lizzo. Sketches include: I Wanna Live on a Mountain, Let Me Rate You, Beach Narc, Kid Pigs, In the Year 2053, My Roommate Is God and Fruit Blood: Don't Make Me Laugh.
Special guest star Andre 3000. Sketches include: Vin Diesel: The Ride, Kidney Stone Fairy, Perv Alert, Human History with Andre 3000, Where Tom Hardy At?, Two Sided Dice and Selena Gomez Stares at Fire.
Special guest star Lizzo. Sketches include: Baby Sleuths, Poompf, Ilana Glazer Does Accents, Pre-Teen with a Predator Head, Coked Up Paddle Boarder and Fruit Blood: This Is How We Screw.
Special guest star Chelsea Peretti. Sketches include: Spy on Your Lover, Wrong Face, Humpington, My Dog Is a Ghost, Hamster Band, "Something I Read" with Chelsea Peretti and Fruit Blood: #27.
Special guest star Lizzo. Sketches include: Jabber Honkey: An HBO Miniseries Event, TV Guidance Counselor, Polygamists of the Trees, Nerf Dad, Man Things, New Barbies and Fruit Blood: Haircut.
Special guest star Lizzo. Sketches include: Fluvia's Horse Battle, Hippie Hair Businessman, Kitty in a Close-Up, Morphers, iJet, Buyer's Remorse, White James Brown, Fuck Your Pink Box and Fruit Blood: Holes.
Special guest star Jeffrey Tambor. Sketches include: Bruce Willis In: Bruce Willis, Crimplestiltskin, Wise Advice from Jeffrey Tambor, White Power Rangers, Jennifer Misty's Christmas Prayer to Y'All and Fruit Blood: Sex Cave.