In the town of Fairview there's a street called Wisteria Lane; a peaceful cul-de-sac with manicured lawns and beautiful houses. It's a place where you know all your neighbors and your neighbors know all about you. It's the perfect suburban fantasy.But, behind every picket fence there are secrets. And, in every seemingly happy home, you'll find jealousy, lust, passion, and sometimes... murder.
Paul Young, now out of prison, returns to Wisteria Lane with an enigmatic new wife; Susan, Mike and M.J. live in an apartment on limited funds; Lynette's successful college friends pays the Scavos an unexpected visit.
Lynette is angry when Renee starts spending a lot of time with Tom; Bree finds herself falling for Keith (Brian Austin Green); Susan feels guilty about her side job.
Susan is less than pleased when she finds out that some of her best and sexiest internet show moves are being copied by a competitor (guest star Rebecca Creskoff), and Gabrielle hires a private detective to look into an important matter, unbeknownst to Carlos. Meanwhile, Lynette is stunned when Tom's doctor prescribes him a rather unorthodox remedy for his depression, and Renee invites a reluctant Bree to go clubbing with her in order to engage in some local man-hunting.
Susan is horrified when she discovers that she has become the face of the provocative internet company she's been secretly working for and is now the cover model for their outdoor billboard ads; Gabrielle tells her coveted secret to the ladies; Renee finds out that Bree is a grandmother and uses it to her advantage in an attempt to steal Keith away and have him for herself; Lynette takes advantage of daughter Penny's generous offer to help look after the baby; and Paul purchases the home he shared with Mary Alice, against wife Beth's wishes.
Susan's days as a sexy internet sensation may be coming to an end after she angers an important client and incurs the wrath of her boss, Maxine; Renee and Gabrielle are headed for a smackdown after each of them reveals an intimate secret about the other to the wrong people; Bree finds herself exhausted by younger lover Keith's sexual stamina; Lynette is angry with Tom after he asks his mother to become the baby's nanny without talking it over with her first; and housewife Emma Graham puts on a cabaret show -- with the aid of saxophonist Dave Koz -- with surprising results.
Susan is forced to reveal her secret to Mike; Juanita becomes suspicious of Gaby's interest in Grace; Lynette is worried about Tom's mother's memory lapses; Bree learns a secret about Keith; and Paul takes Beth out on a date.
A reluctant Susan accepts Lynette's offer to be baby Paige's nanny; Bree meets Keith's parents; Renee makes a proposal that Lynette can't refuse; Gaby fears that Bob might be trying to seduce Carlos after they become friends; and Beth begins to question Paul's motives for returning to Wisteria Lane.
Thanksgiving on Wisteria Lane finds Gabrielle and Carlos hosting Carmen, Hector and Grace to a bountiful feast. But the Solis's discover some surprising news about the Sanchez's that could threaten their time with Grace. Meanwhile, Bree invites Keith's parents to partake in Thanksgiving at her house and learns some family secrets; Susan butts heads with Lynette over her sleep training techniques for baby Paige; Renee continues to remind Tom about their past; and Beth tries to uncover more about Paul's past misdeeds.
Gabrielle desperately tries to figure out a way to keep Grace in her life; Keith plans a very special dinner with Bree; Tom is angry at Lynette for not disclosing his special attributes to the other ladies; Renee tells Susan a deep, dark secret; and Paul's plan for Wisteria Lane is revealed
Paul's nefarious plan for Wisteria Lane is put into full effect. Juanita discovers that she isn't Gabrielle's biological daughter, and Bree invites Keith (guest star Brian Austin Green) to move in with her, whilst Tom is confronted about his past indiscretion with Renee.
Paul finds out that Beth is Felicia Tilman's daughter while a therapist asks Carlos and Gabrielle to erase Grace from their lives. Susan finds out she needs to go to the hospital every 48 hours and Renee finally tells the secret between her and Tom to Lynette. Orson returns and Bree gets torn apart with her feelings between Orson and Keith and detectives try to find the person responsible for shooting Paul Young.
Susan's mother and aunt visit her at the hospital, Lynette plots revenge against Tom, Gabrielle becomes increasingly obsessed with getting Grace back and Bree wants to be friends with Beth.
Lynette feels her mother (guest star Polly Bergen as Stella) is marrying Frank (guest star Larry Hagman), an abrasive and obnoxious man, for all the wrong reasons, and thus tries to talk her out of it. Meanwhile, Carlos becomes concerned when he learns about Gabrielle's obsession with her doll, and Bob and Lee hire a non-maternal Renee to decorate their newly adopted girl's bedroom. Bree runs into Keith's ex-girlfriend (guest star Rochelle Aytes as Amber) and learns some shocking news about his past, and Susan tries to befriend a curmudgeonly man (guest star Gregory Itzin as Dick) who has given up on ever finding a kidney donor. In the meantime, Paul appears to have some plans for Beth (guest star Emily Bergl), as he books a trip for the two of them to a remote cabin in the woods.
While in therapy, Gabrielle learns the truth about her past; Keith becomes suspicious about Bree's secret; Lynette's mother tells a lie to a coroner about Frank's death; Mike confronts Zach about Paul's shooting; someone makes arrangements to give Susan a new kidney.
Gabrielle and Carlos head to Texas to visit Gabrielle's stepfather's grave; Lynette prohibits Porter and Preston from bringing home girls; Renee tries to use Susan's dialysis to help her get into a restaurant, but fails.
Susan vows to get the most out of life when she learns that her dialysis isn't working and that, unless she receives a kidney transplant soon, she will die. Meanwhile, jealous of Lee and Bob's adopted daughter's routine for an upcoming school talent show, Gaby pressures Juanita to come up with a number that will outshine everyone; Bree makes it her mission to find a kidney donor for Susan; Lynette puts a plan into action to discourage a clearly non-maternal Renee from adopting a baby; and Beth Young struggles to figure out what to do with her life after Paul kicks her out of the house.
Paul tries to stand between Susan and her kidney transplant; Felicia is released from prison and swears revenge against Paul; Gabrielle is furious about a neighborhood party planned by Renee; Tom is caught between working with Carlos and a job opportunity; Andrew's drinking concerns Bree.
Believing she's on a winning streak after undergoing a successful kidney transplant, Susan begins to think she's invincible and starts to gamble with the little money she and Mike have, convinced she can't lose. Meanwhile, Bree desperately tries to stop Andrew from admitting to Carlos that he was the one who accidentally killed his mother years ago, and Renee helps introduce Lynette to the world of high class, frivolous shopping now that Tom's bringing in the big bucks with his new, high-powered job. Felicia (guest star Harriet Sansom Harris) moves back into the neighborhood and tries to convince an extremely suspicious Paul that she wants to bury the hatchet and try to be civil to one another.
Gaby covertly meets Bree when Carlos forbids them from being friends after learning the truth about his mother's death. Meanwhile, saved by the late Beth Young's kidney donation, Susan begins to have some inappropriate dreams about Paul; Lynette is reluctant to be the "plus one" when she accompanies Tom to a weekend conference featuring the nation's top executives; and Felicia tries to regain Mrs. McCluskey's trust in her campaign to bring down Paul Young.
With Gaby and the girls temporarily staying at Bree's house, Bree must lay down the law and demand discipline before Juanita and Celia destroy her home. Meanwhile Tom hires Lynette and Renee to redecorate his office - but Lynette has her own ideas of what she thinks Tom needs as opposed to wants; and while continuing to help nurse Paul back to health, Susan discovers that Felicia has been released from prison and is back on Wisteria Lane.
Paul begins to suspect that Susan is responsible for his rapidly declining health; Lynette and Tom butt heads over where to go on their family vacation, as well as which one of them will set it up; Gaby shows Juanita a horror movie and has to pay the price when her daughter becomes too scared to sleep in her own bed; and Bree runs into some trust issues when she goes out on a date with a detective.
Gaby is stunned to learn the identity of the mysterious man who has been stalking her; Lynette and Tom attempt to put the spark back into their marriage by spending a few days alone together at a romantic Bed & Breakfast; after being placed under arrest for allegedly poisoning Paul, Susan must convince the police that she was being framed for the deed by Felicia; Bree begins to suspect that her new boyfriend may be gay.
In the wake of another attack, Angie decides the time has come for her and her family to leave Wisteria Lane; Bree and Susan are literally up in arms with one another as Bree's affair with Karl becomes increasingly difficult to hide; Lynette's pregnancy causes a rift with Gaby; and a confrontation between Mike and Katherine leads to a harmful and unexpected blow.
Gabrielle and Lynette's friendship is on the brink of collapse, whereas Bree and Orson come to an agreement about their marriage. Meanwhile, Susan hatches a plan to help an irrational Katherine, and Danny's vital mistake might cost Angie her freedom. In the meantime, Christmas cheer is curtailed when disaster strikes, as a plane crashes down on Wisteria Lane, putting lives in peril.
In the aftermath of the plane crash, the residents of Wisteria Lane think about what their lives might have been like had they made different choices. Susan contemplates a life with Karl had she not left him. Bree considers life without Orson. Lynette thinks about a future with her unborn twins. Carlos reflects on how Gaby would be as an over-protective mom and Angie ponders the consequences should her secrets be revealed.
Gaby and Angie challenge each other's parenting skills, Susan befriends a stripper and takes her under her wing, Lynette and Tom argue the merits of their new therapist, and a concerned Bree keeps a watchful eye on Orson for fear he may take his own life.
Former exotic dancer Robin will have a profound effect on Susan's friends with three teenage boys at home, Lynette will keep a watchful eye; Bree picks up a few tricks to engage Orson; Gaby looks for help with troublesome niece Ana; and Katherine will find a friendly companion.
Having never had the chicken pox herself, Gaby stays with Tuc and Bob and is reminded of what it's like to be single again; Lynette and Tom forget Penny's birthday; Bree hires a promising new employee; Susan cheats on Mrs. McKluskey; Katherine makes a surprising discovery and Angie grows concerned over Danny's disappearance.
While in the Big Apple, a chance encounter with supermodels Heidi Klum and Paulina Porizkova leads Gaby to an unexpected revelation about herself. Meanwhile, Lynette and Tom are in for a big surprise when Preston returns from Europe; Mike is determined to show Susan what a man he is after feeling emasculated; Bree discovers a shocking connection to her new employee, Sam; and Katherine is confused over her feelings for Robin.
Angie’s ex-boyfriend, Patrick, emerges after her trip to New York. Meanwhile it’s game on between Gaby and Susan, as they go to shameless lengths to top each other’s kids; Lynette believes there’s more to Preston’s fiancée than she’s letting on; Bree invites Sam over for a family dinner; and Katherine comes out of the closet.
Determined to derail son Preston's marriage to Irina, Lynette discovers the truth about her future daughter-in-law. In the meantime, Gabrielle offers to help out Bob and Lee in the most generous way, but does not consider the consequences. Bree begins to question whether Sam has a hidden agenda, and Susan gets creative to help Mike with his finances. Unbeknownst to Angie, Danny meets Patrick Logan for the very first time.
The Fairview strangler has been living among the women of Wisteria Lane. He once caught Gabrielle and Carlos in an intimate moment. Bree offered him a job and some dating advice. Susan encouraged his passion for art. Lynette will show him kindness and generosity. But... who is he?
Angie comes face to face with her ex, Patrick Logan, after years on the run. Meanwhile, Gaby and Susan plan an elaborate scheme against their husbands, Lynette sees a darker side of Eddie, and Bree meets a woman who knows Sam all too well.
Lynette comes to a shocking realization about Eddie. Meanwhile, Angie discreetly relies on Gaby for help when Patrick threatens the life of her son; Bree offers Sam a generous payoff to walk away; and Susan and Mike's financial woes result in the ultimate sacrifice.
Gaby risks her safety to help Angie; Lynette's fate and that of her unborn child lie in the hands of Eddie; Susan comes to grips with her financial woes; Bree considers confessing a secret she's harbored for years; and Angie must submit to Patrick's demands in order to protect her son.
While Bree gives Chuck a ride, a smell becomes noticeable; Gabrielle seeks out a priest in order to help Carlos with his problem; Ben Faulkner, a new neighbor, meets Renee; Susan withdraws from her friends because of what happened to Alejandro.
Gabrielle teaches Carlos how to dance on a strip pole; Susan seeks out a punishment for feeling guilty; Renee bonds with one of the customers at a senior center; Tom and Lynette wonder why Parker was at a late night party; Bree discovers Chuck's past.
Lee has a problem with Jenny; Susan and Carlos attempt to find the people responsible for tagging the wall with graffiti; Lynette grows suspicious of Lydia and her fiancé.
While at a yoga class, Lynette and Renee spy on Jane, Tom's new girlfriend; Gabrielle tries to affect change at a PTA meeting; Bree discovers what Danielle is up to; Susan battles with art class teacher Andre Zeller.
Tom and Lynette visit a couples counselor about their separation; Bree tries to help a city council about the homeless; Carlos is in a guilty situation; Susan is embarrassed about Andre's students being naked in class.
Susan grows suspicious about Amy's affair with Andre; a delivery man tries to deliver a package for Lynette; a man speaks to a sponsor from A.A. about a blackout; the housewives are in the woods with the shovels, but they're being watched.
Bree is stunned when she learns who dug up the body of Gaby's stepfather; jealousy rears its ugly head when Lynette begins to spread untruths to daughter Penny about Tom's new girlfriend; Gaby and Carlos must convince Lee and Bob that Juanita and Celia aren't the bad seeds that they used to be when they want to name them in their will as guardians; and Susan desperately searches her inner self to find what inspires her in order to better her art and impress her hard-to-please art teacher, Andre.
Detective Chuck Vance begins harassing Bree as his suspicions about her involvement in the disappearance of Alejandro grow; after using the murder of Gaby's stepfather as inspiration for her art school projects, Susan must find a way to graciously decline art school teacher Andre's (Miguel Ferrer) invitation to display and sell her paintings at a gallery showing; when Carlos's drinking gets in the way of his ability to work, Gaby goes to The Office in an effort to save his business from losing a multi-million dollar account; and on the occasion of their 22-year anniversary, Lynette comes up with a plan to try to salvage her marriage to Tom.
Gabrielle, thinking the worst, goes on a frenzied search for Carlos after he unexpectedly checks out of rehab. Meanwhile, a desolate Bree goes on a drinking binge and finds herself in a desperate situation.
Acting on a misconception, Renee discovers just how desperate Bree is feeling, Gaby is concerned that Carlos may have been involved in another murder, and Lynette make a confession to Tom.
While in Oklahoma, Susan learns that the late Alejandro has been sexually abusing his 15 year old step-daughter, Marisa, just like he abused Gabby years earlier. Meanwhile, Bree gets an unpleasant surprise from a man she meets in a bar, Gabrielle tries to bluff her way through a business dinner in order to woo a potential client for Carlos, and Mike catches Ben doing something he shouldn't do to try to salvage his faltering real estate project.
Karen McCluskey finds out about Bree's sex life and interferes, Bree bumps into one of her many conquests unexpectedly, Gabby shares her past with the widow of Alejandro, and after introducing them, Renee ends up paying the price when the date between her hairdresser and Lynette doesn't go well.
Bree's sexual escapades are getting out of hand and help comes from an unexpected source, Susan learns that Julie is pregnant, and Gabby has to deal with a situation at Juanita's school.
Susan discovers the identity of the father of Julie's baby, and Orson makes it his duty to nurse Bree back to health. When Mrs. McCluskey throws Roy out of the house, Gabrielle takes him in and is reluctant to help get them back together when he proves to be an invaluable disciplinarian to her kids. Meanwhile, after getting used to her alone time, Lynette is furious when Porter and Preston are evicted from their apartment and try to move back home, and Mike informs Renee of Ben's dire circumstances with a loan shark.
Susan offers to help the father of Julie's baby raise the child; Bree agrees to go to Maine with Orson - perhaps for good; Karen pleads with Gaby not to tell Roy about her condition; and the loan shark who threatened Ben sets out to ruin Renee.
Susan talks Mike into going to the police when she discovers that Ben's loan shark is out to get him; Mrs. McCluskey, who's dying of cancer, asks Bree to help her commit suicide; Tom's girlfriend, Jane, stuns Lynette at Penny's birthday party; Carlos behaves oddly on his first day back at work, and Gaby is worried.
On the day of a beloved Wisteria Lane resident's funeral, each of the housewives recalls the effect this person had on her life. Meanwhile, Bree is stunned when she's called in for questioning about the murder of Gaby's stepfather, Alejandro.
Bree is not so sure about Andrew's upcoming marriage; Gabrielle tries to find work in an employment agency in order to teach Carlos and the kids a lesson; Lynette plans to win back Tom at any cost; Susan's parenting skills concern Julie; Ben asks Renee to marry him.
Carlos gets concerned about Gabrielle's new job; an affair makes Susan suspicious; the police ask a hotel owner about Alejandro's whereabouts; Bree needs a lawyer's help in order to get her charges of Alejandro Perez's murder cleared. Jane served to Lynette their divorce papers.
With Mike gone, Susan attempts to build a car for MJ's father-and-son school soapbox derby; Bree's attorney, Trip, learns of her previous drunken sexual spree and needs her to come clean about it in order to help strengthen her case; Lynette tries to cause some negative friction between Tom and his girlfriend, Jane, by flirting with his boss and getting him to pile more work on her estranged husband; Gaby is furious with Carlos when he tries to poach one of her rich, personal shopper clients (Doris Roberts) and talk her into helping with his newly formed charity organization; and Renee discovers that Ben is keeping a secret from her about his involvement with Bree -- and the body found at his work site.
In the penultimate episode leading into the two-hour finale of this landmark series, as her trial nears, Bree begins to fall for her attorney, Trip; Susan becomes concerned when Julie doubts Porter's commitment to be a hands-on father to their unborn baby; as Tom gets closer to being transferred to India for his job - thanks to Lynette - she begins to have second thoughts and tries to convince his boss to rescind the move; and the ladies are shocked about Gaby's nonchalant attitude as Bree continues to stand trial and take the fall for Carlos in the murder of Alejandro.