In this supernatural crime series, Seth Gecko and his violent, unpredictable brother, Richard "Richie" Gecko, are wanted by the FBI and Texas Ranger Freddie Gonzalez after a bank robbery left several people, including policemen and Gonzalez's mentor Texas Ranger Earl McGraw, dead. Heading for the Mexico border pursued by Gonzalez, the Geckos encounter former minister Jacob Fuller and his family, whom they take hostage by commandeering the Fuller's RV. Drug lord Don Carlos reroutes them to a strip club populated by vampires that all must fight until dawn in order to survive.
The Gecko brothers finally call a truce and work together to find Malvado's headquarters; Carlos, unhinged from the Labyrinth, abducts Santanico and claims her for himself. And Kate enlists Freddie’s help as she attempts to save her brother.
Uncle Eddie helps Richie and Seth make a plan to complete Santanico's revenge. Meanwhile, Freddie and Kate encounter an unexpected foe following Malvado's attack.
As the pieces of the big job fall into place, the uneasy trust between brothers and partners crumbles in the light of the betrayals and new loyalties.
Santanico confronts Malvado with Seth's help; Richie and Kate must stop Carlos and Scott from overturning the ancient prophecy and taking control of a powerful evil.
Seth and Santanico clash with Richie over his betrayal, while Carlos and Scott aim to take Malvado’s empire and unleash culebra frenzy on the world.
Robber Seth Gecko and his violent, unpredictable brother, Richard 'Richie' Gecko shoot their way south after a bank heist in Abilene, Texas.
The Gecko Brothers flee the liquor store with Ranger Freddie Gonzalez following. Richie's visions escalate. The Geckos nearly collide with the Fullers, a troubled family making their own desperate journey to Mexico.
While Richie deals with his visions, Seth and Carlos plan to cross the border. Meanwhile, the Fullers' RV breaks down and Ranger Gonzalez asks for help.
The Gecko brothers attempt to leave the hotel and take the Fuller family hostage, but Freddie arrives and complicates the situation.
Seth escapes the motel and leads the Fullers' RV to the border. Meanwhile, Richie deals with an irrational fear; and Jacob is determined to get his children safely across the border.
The Gecko brothers and the Fuller family find themselves in over their heads whilst Seth's deal with Carlos might not happen after all.
Gecko brothers and the Fuller family are watching the Santanico Pandemonium as Ranger Freddie Gonzalez shows up to exact revenge.
As Santanico tries to turn Richie to her cause, Freddie confronts Carlos about his destiny and the temple's mysterious past. Seth, the Fullers, and Sex Machine battle their way deeper into the temple, where they meet an unexpected ally.
Seth and Richie have to attempt the temples labyrinth. Jacob and Kate confront Scott about his transformation. Freddie follows a new lead in the case.
The Geckos have been demoted to “collectors”, while their organization has been infiltrated by a mysterious new enemy hell-bent on destroying them, the Lords, and all culebras.
Seth and Richie seek help from Santanico; Freddie and Ximena have an encounter with Brasa.
Freddie Gonzalez teams up with an old enemy; Seth and Richie track down an ancient hunter.
Ranger Freddie Gonzalez teams with an old enemy; the Geckos must defend against the Jaguar Warriors.
Seth and his team protect civilians from cannibal attacks.
Richie wakes up in an abandoned asylum after being abducted; Seth goes to save Richie.
Santanico returns with a secret and leads the Geckos to Lord Venganza.
The Geckos are going after Amaru, as she plots to regain her true form and open the gates of Hell.