High concept and ambitious, Hit and Miss follows Mia (Sevigny), a contract killer with a secret: she's a pre-op transsexual. Mia's life is sent into a tailspin when she receives a letter from an ex-girlfriend dying from cancer revealing that Mia fathered a son eleven years ago. Faced with a difficult decision, Mia becomes the guardian to a new family, a choice that forces her to mix her killer instincts with her newly acquired maternal ones. Hit and Miss tells the story of a lethal killer at the heart of a troubled family and how all of their lives will be dramatically changed forever
An assassin with a secret, Mia's life is changed forever by a letter from her ex.
Mia ends up becoming the victim after her new brood refuse to accept her and her landlord wants revenge.
A romantic opportunity comes up for Mia, but her secrets end up being compromised after a hit goes violently wrong. Riley has a problem of her own to deal with.
Following a huge confession from Riley and progress with Ben, Mia attempts to keep the her home and work lives separate, but they end up coming to a full-on collision.
Eddie tasks Mia with executing a demanding hit after he helps her dispose of a body, and Ben struggles to comprehend his feelings for Mia after discovering that she is Ryan’s father.
Mia ends up going missing in action. Eddie is furious and Riley is arousing suspicion. The brood find themselves under fire from everywhere.