When Charlie is diagnosed with cancer, the prognosis is favourable - he's young and healthy and the cancer, non-Hodgkin's lymphoma, has been caught early and is a type of cancer that responds well to chemotherapy. Suspicious of drugs and modern medical treatments, Charlie refuses the chemo in favour of a more natural, alternative form of healing.His oldest friends Joel and Tess fear he's written his own suicide note so they decide to hold him hostage and administer the chemo themselves with the help of Nadia, an unstable, alcoholic oncologist.
Just as Joel has reconnected with his friends he discovers that Charlie has been diagnosed with cancer - Hodgkin's Lymphoma. And he's horrified to learn that he is refusing chemotherapy. Joel recruits Tess and Nadia to try and persuade Charlie to change his mind, but to no avail. Refusing to give up, Joel uses his 'dirty divorce money' to rent a remote country house and buy black market chemotherapy drugs. He enlists Tess to join him in kidnapping Charlie and sedating him while they administer the chemo. However, doing so is not quite as easy as they hoped, and Joel decides to hire Nadia to stay with them as their live-in doctor. All is going to plan until Charlie tries to escape!
After Charlie's attempted escape, Joel and Tess decide they need to keep a closer eye on him. Tess is tracking the story of Charlie's disappearance on the web as the police launch an appeal. The news of his cancer diagnosis has leaked, and the most popular theory is suicide. Good news for Joel and Tess, terrible news for his wife Kira and the kids. So as not to arouse suspicion, Joel decides he should go and see Kira. However, while comforting her, he finds himself enjoying taking on Charlie's role in this ready-made family. Meanwhile, back at the house, Nadia is drawn into increasingly frank and intimate chats with Charlie, whose 'enlightened spiritual guru' act convinces her to try to clean up. Has he completely won her over or is he just using her to plan another escape?