Angus "Mac" MacGyver, creates the Department of External Services (DXS), a clandestine organization within the U.S. government where he uses his extraordinary talent for unconventional problem-solving and vast scientific knowledge to save lives.
Using a cell phone and soccer ball, MacGyver and the team search for a Navy SEAL who is believed to be alive in captivity in the Middle East.
Using a necklace and a microwave transmitter, Mac and the team attempt to locate Riley after her first solo mission with a group of dangerous hackers goes off the rails.
Using cuff links and wire, MacGyver and the team go undercover in a high stakes casino to steal diamonds from a vault before a terrorist group gets there first and trades the jewels for a weapon of mass destruction.
When Murdoc drugs and kidnaps MacGyver, Mac uses a needle and his teeth to escape and join the team to save Murdoc’s next victim.
The team is pulled away from their Halloween plans when they head into the dreaded Bermuda Triangle to retrieve the Vice President’s son after his plane goes down with a mysterious prisoner on board.
Using a cassette player and a plastic bucket, Mac and the team attempt to extinguish a massive oil wellhead fire in a Nigerian village, set by a rebel group, which is trying to topple its government by destroying their most valuable resource.
MacGyver uses a heater and tabasco sauce to help a key presidential candidate in Ecuador receive a heart transplant he desperately needs after a rebel group tries to sabotage delivery of the organ.
When MacGyver and Jack “steal” a priceless painting, using a table cloth and a shoe lace, in order to draw an infamous stolen art dealer out of hiding, they wind up getting conned out of the painting by the dealer’s team. Also, Riley’s estranged father, Elwood, asks to be part of her life, and Matty sends Bozer to a spy training camp.
Mac and the team follow a group of Indonesian mercenaries who are transporting a lethal amount of stolen nerve gas in the hopes of tracking them to their dangerous leader. Also, Jack confronts Elwood about Riley, and Bozer is pushed to his limit in spy school.
When 32 college students are stranded on a research ship in the Arctic Ocean with no heat and erupting fires, Mac develops an emotional connection to the group leader, via video chat, as he relays how to stay alive as they await a rescue ship. Also, Jack kidnaps Elwood to find out what scam he’s up to next, and Bozer’s feelings toward Leanna grow stronger.
The LAPD interrupts the team’s Christmas celebration to arrest Mac for terrorism when they find a body in a building destroyed by a bomb Mac built.
When Mac and Jack are trapped inside Mac’s house, which his nemesis, The Ghost, has rigged with explosives, Mac uses a karaoke mic and an audio transformer to let the team know that this bomb is a distraction for a bigger one. Also, through flashbacks, Mac and Jack’s contentious first meeting unfolds.
While Mac participates in a challenge for government operatives to create robotic combat machines, Mac must help his biggest competitor, Allie, when her vehicle is hacked and heads to the Pentagon. Also, Jack attends his high school reunion, hoping for a showdown with his old rival who beat him out for homecoming king.
When the team heads to New Orleans to track down the con artist who is posing as the wife of “Duke Jacoby,” one of Jack’s old CIA aliases, Jack finds himself in jeopardy when “Duke’s” old enemies resurface looking for revenge.
After one of Murdoc’s go-to assassins agrees to hand over Murdoc to MacGyver in exchange for $10 million, the team finds itself protecting Murdoc from his former mentor, Nicholas Helman, who wants him dead. Also, Jack realizes he may still have feelings for Riley’s mother, Diane.
MacGyver, Leanna, Riley and Bozer pose as honeymoon couples at a resort in order to gain information about a Serbian war criminal from his newly married son. Also, Bozer wonders if Matty knows about his relationship with Leanna, and Jack recruits Elwood to help him break into Matty’s home.
Mac, Jack and Riley set out to find a mobster-turned-informant after he’s kidnapped and taken to Chernobyl by an international crime boss who’s worried he will deliver incriminating information to the CIA. Also, Bozer struggles to keep a secret from Matty.
When Matty and the team search for a former government tech who stole classified intel and has been evading capture, they reunite with the Coltons, the family of bounty hunters, who are pursuing the same man for different reasons.
As Mac and the team investigate the suspicious death of Dawn’s CIA supervisor, the evidence leads to a dirty CIA agent and a massive counterfeiting ring.
Mac and Jack attempt to rescue a billionaire’s son after he is kidnapped by a former Navy SEAL who uses an EMP weapon to cut off power and communication lines to the Shanghai skyscraper where the boy lives.
While MacGyver is in Puerto Rico helping his friend rebuild his hurricane-damaged home, he is taken hostage in the bank his friend manages when robbers attempt to steal $2 million.
Mac and Riley are attacked by a group of masked men after the government calls them in to examine a mysterious object that crash-landed in the Nevada desert. Also, Riley uncovers new information about Mac’s father but questions whether to deliver it to him after he says he needs to move on.
Three months after quitting the Phoenix Foundation and moving to Nigeria, Mac puts aside his differences with his father and returns when he hears Jack is the target of a murderous dictator he double-crossed.
When Jack receives an emergency distress signal from one of his old Delta buddies who is falsely accused of terrorism in a foreign country, MacGyver and Jack quickly recruit the rest of Jack’s old Delta team and stage an unsanctioned rescue op.
MacGyver, Riley, Bozer and Leanna go undercover on a college campus to smoke out a deep-cover operative who is recruiting students to carry out deadly attacks around the world. Also, Jack joins bounty hunter Billy Colton in the hunt for a bail jumper but is concerned when he finds out Billy offered Riley a job.
MacGyver and Riley, with the help of Vasil, a distraught father, must find a way to drive a tanker filled with liquid oxygen through a region occupied by rebels and deliver it to a children’s hospital before they run out. Also, Riley helps MacGyver decide whether or not to allow his father back into his life.
When Oversight’s attempt to capture a drug cartel’s leader goes bad, MacGyver and Jack rush to Mexico to pull their boss out while racing through the heart of the country during Dia de Muertos celebrations. Also, Bozer and Riley use Halloween as a distraction to gather intel on a man accused of treason.
Murdoc abducts MacGyver’s girlfriend, Nasha, to force Mac to help him rescue his son, Cassian, from a kidnapper. Also, a dangerous individual from Murdoc’s personal life shows up, giving Mac a glimpse into the villain’s past.
Matty sends MacGyver and team to Ghana to recover a hard drive from an e-waste landfill that is run by a powerful and violent man. But when Matty refuses to reveal what’s on the drive, other than a mysterious file called “Dragonfly,” the team speculates about what could be so important to her.
MacGyver and the team set off on a dangerous capture operation after an Irish military intelligence officer approaches them claiming to know the whereabouts of “The Ghost,” a lethal bomb maker whom Mac has been hunting for years.
When a vial containing a deadly virus is stolen from the Center for Disease Control in Atlanta, MacGvyer and team race to recover it before the thief unleashes a global pandemic.
Matty reveals a shocking secret to the team: she has a husband who’s been undercover in a criminal organization called D-Company for eight years. When his status as a CIA agent comes out, Matty needs MacGyver to find and extract her husband before it’s too late.
Angus “Mac” MacGyver and Jack Dalton, special agents for the Department of External Services (DXS), join forces to recover a missing bioweapon that has the ability to destroy hundreds of thousands of people with one single drop.
MacGyver and the team attempt to rescue Sarah, Jack’s former CIA partner/ex-girlfriend who went missing in Venezuela after she obtained evidence to take down an international arms dealer.
MacGyver and the team are in Malaysia to extract a terrorist group’s money man, Ralph, who holds key intel on an impending attack. But the mission goes south when the man is shot, and now, with only a driver’s license and hand sanitizer available, MacGyver must keep Ralph alive in order to learn the terrorists’ plans.
Mac and Jack partner with older versions of themselves, a Russian bomb programmer and his estranged handler, to shut down a Soviet-era warhead in Moscow. But when the antiquated computer needed to disable the warhead becomes inoperable, Mac must find a way to fix it with only duct tape and wire in time to prevent a new Cold War.
Using only an armrest, a curtain rod, and a toothpick, MacGyver must fix a sabotaged train in order to protect a whistleblower who has proof that her boss is selling weapons to U.S. enemies.
Using only a wrench and rope, MacGyver must diffuse a bomb set near the United Nations by his old nemesis, “The Ghost”, a notorious criminal whose work killed his mentor, and track him down before he strikes again.
MacGyver is tasked to go undercover as an inmate in a maximum security prison to break out El Noche, a notorious drug kingpin, using only batteries and salt, and track him to his cartel’s secret location and dismantle it.
When MacGyver comes face to face with Murdoc, an international assassin hired to kill him, Mac must defend both himself and Bozer, armed with only a corkscrew and paper towel rolls. Also, Bozer feels completely betrayed when he finally learns Mac’s true identity.
With only a chisel and matchbook, MacGyver and team must defend themselves the U.S. embassy workers in Latvia from extremists who are attempting to retrieve their leader. Also, Bozer faces a big decision now that he knows who Mac really is.
Mac and the team have no time to reminisce while visiting Mac’s and Bozer’s hometown when they immediately start searching for a kidnapped prodigy from Mac’s old middle school, Valerie. With just pliers and speaker wire available, Mac works doggedly to rescue the young genius he has so much in common with.
MacGyver and Jack search for Riley, using a microwave and a power strip, after she mysteriously disappears and hacks into the NSA, possibly unleashing World War III. Also, Bozer goes on his first official mission, and Jack opens up about his history with Riley’s mother, Diane.
Using a screwdriver and bug spray, MacGyver must find the U.S. government mole who is leaking classified intel to the organization that is trying to take down The Phoenix Foundation. Also, Sarah returns to help with the mission, and Nikki reappears, but Mac can’t tell which side she’s on.
On the way back from capturing a war criminal, Mac and Jack’s helicopter crashes in a remote area of Kazakhstan, injuring their pilot and allowing their prisoner to escape with Jack’s gun. Using a large blade and a water bottle, MacGyver must get help as the pilot’s condition worsens and before the war criminal takes them as prisoners.
Using a fish scaler and some fishing wire, Mac and Jack must track down a corrupt FBI agent who has framed a man for murder. Also, everyone on the team is terrified to get their first performance review from Matty, their tough new boss.
While tracking down the dangerous fugitive Aaron Deckard, Mac and Jack face the notorious Colton family of bounty hunters who already kidnapped their mark. Now, using a hook and a car cable, Mac must extract the criminal from the Colton’s, who are unaware of the deadly situation they’re in. Also, Bozer and Riley try to hack into Jack’s CIA file to find out about his history with Matty.
Bozer’s first overseas mission goes terribly wrong when Mac and the team are blamed for a terrorist bombing and the Phoenix Foundation is forced to disavow them. Using a ruler and coconut oil to make disguises, the team must avoid authorities and clear their names without any support from back home.
When Mac and the team travel to Hawaii to aid in earthquake relief efforts, they team up with Chin and Kono from the Five-0 task force to rescue a group of government scientists trapped in a building. However, as they work on the complicated rescue, a group using the chaos as a distraction aims to steal the top-secret weaponry from the scientists.
Mac and Jack help Mac’s close friend from M.I.T. after she fakes her own death to prevent someone from killing her in order to suppress her scientific research.
When the team intercepts a terror group's message meant for Murdoc, Mac poses as the psychopath to save the intended target and find out why they want Murdoc to assassinate him.
Season Finale. Murdoc moves forward with his plans for revenge against MacGyver by recruiting his recently released former cellmate to infiltrate the Phoenix Complex as a "lab technician" and kill every agent inside.