Zsaylnn, once known as the "Fat Girl Rock Star" - married a man who loves large women. Now weighing over 600lbs, she urgently needs to lose weight to be the mother her daughter deserves. Can Zsalynn succeed with a husband who doesn’t support her goals?
A 46-year-old Chicago woman battles depression in the wake of a suicide attempt and hasn't left her basement in two years, but hopes that a surgical procedure in Houston can save her life.
A 46-year-old woman bedridden for four years moves from Maryland to Texas to have gastric bypass surgery, but is reluctant to make real lifestyle changes that could improve her health.
A 700-lb. man tries to take control of his life when his wife is ready to leave him and he's forced to downsize his business.
A 22-year-old married woman in Mississippi hasn't left her house in two years, but her family haven't done her any favors by enabling her terrible eating habits.
A woman who weighs more than 600 pounds experiences a sudden loss, and must think about her own life and what will happen to her children.
A man who weighed 700 pounds begins his second year of weight loss and discovers a promising new relationship; a formerly 600-lb. woman's responsibilities may distract her from achieving her goal.
A 23-year-old woman who weighs more than 600 pounds is dependent on her family and her boyfriend for the simplest tasks, so she decides to have weight-loss surgery that will force her to move 2000 miles away from her loved ones.
Susan is 37 years old and has never lived on her own because of her weight.
Brittani ha sposato un uomo che ama le donne in carne, ma ora lei pesa circa 300 chili e questo non fa bene al loro matrimonio. Dopo la chirurgia, la donna deve costruirsi una nuova vita.
After gastric bypass surgery, Chad quickly sheds his dangerous weight but faces a medical crisis when he does not follow the doctor's orders.
600-pound June copes with the tragic death of her son by eating. After gastric bypass surgery, she must confront the emotional issues driving her food compulsion. If she can stay on track, she can become the mother she desperately wants to be.
With the support of his fiancee, Kathryn, Robert turns to Dr. Nowzaradan in a desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema and nearly 900 pounds.
Tamy's eating addiction has caused her weight to balloon over 500 pounds. She has become a hermit after years of shame, and hopes to restart her life so he can take better care of her son, Zachary.
Fearing that he'll suffer the same fate as older brother David, who is now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.
A former plus-size model and "big is beautiful" advocate, Renee now realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health deteriorates.
A 24-year-old woman weighs more than 600 pounds and is fighting for her life after a difficult childhood with an abusive stepfather and drug-addicted mother.
Octavia has been bed bound for nearly a year when she decides to make a trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.
At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life; she faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.
Robin and her brother Chris are both obese and already lost a sibling to obesity. They plan to visit Dr. Now together when Chris suffers a stroke and can't go. However, Chris's son Garrett, already 600-lbs at age 20, may join the journey with his Aunt.
A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.
Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.
Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.
Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.
Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend, Christian. However, when Christian decides he's had enough and leaves Maja high and dry, she will discover that the only person she can count on is herself.
Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.
Born as "Matthew," Destinee never felt like she fit in; now, having come out as a 600-pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.
Jeanne lives in an unhygienic household with her mother and schizophrenic father; at well over 600 pounds, Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.
Since the death of his mother, Aaron lives at home to care for his aging father, but due to his food addiction, Aaron has to heavily rely on his father for help instead; Aaron must learn to care for himself to avoid eating himself to death.
Kelly is on the verge of immobility when she decided to make the trip to Houston to visit Dr. Now; Her journey gets off to a painful start when a long travel day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital
When Annjeanette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled to overcome her food addiction. Now, she must change her habits to save her life.
When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do. At the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.
A mother of 4, bed-bound for 2 years, Lashanta relies on her kids to keep her cleaned and fed. Her last chance to break the cycle of food addiction that's killing her is to join Dr. Now's program, but it will take a village just to get her out the door.
Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters. If he doesn't lose weight soon, he knows he'll lose either his girls, or his life.
With severe lymphedema, Mercedes can barely stand and cares for her 2 small children with the help of her extended family. Dr. Now can give her the tools to lose weight, but to succeed she must face the trauma inflicted by her late abusive father.
At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting life-saving weight loss surgery. But family conflict and a disagreement may stop her from being able to do what she needs before she even gets the chance.
Weighing over 600 lbs. each, Vianey and Allen are locked in a codependent relationship based on a shared love of food. As they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.
As Steven heals from his weight loss surgery, his brother Justin finally decides to come to Texas to get the same procedure, but his feelings toward Steven immediately begin to sabotage his hopes of surgery.
A year since her weight loss journey began, Janine is still in the 500s and mostly immobile, and now, Dr. Nowzaradan is running out of options for how to treat her if she can't find a way to control her eating habit and start walking again.
Lee's anger issues continue to jeopardize his relationship with Rena and threatens to derail both of their weight loss journeys; a major life event sends Sarah into a depression that she must pull herself out of if she wants to keep losing weight.
In the fourth year of his weight-loss journey, Sean struggles to get past the loss of his mother and live on his own; Dr. Now intervenes to control Sean's eating for a time.
Liz has gone from being bed-bound with lymphedema on both legs, to standing and walking, but old fears are about to threaten her progress; if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.
Pauline's self-destructive behavior continues to be a problem. Chad strives to be a better father and husband as he continues his journey. June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.