Octavia has been bed bound for nearly a year when she decides to make a trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.
Robin and her brother Chris are both obese and already lost a sibling to obesity. They plan to visit Dr. Now together when Chris suffers a stroke and can't go. However, Chris's son Garrett, already 600-lbs at age 20, may join the journey with his Aunt.
Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.
Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success; she must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.
With the support of his fiancee, Kathryn, Robert turns to Dr. Nowzaradan in a desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema and nearly 900 pounds.
Tamy's eating addiction has caused her weight to balloon over 500 pounds. She has become a hermit after years of shame, and hopes to restart her life so he can take better care of her son, Zachary.
Fearing that he'll suffer the same fate as older brother David, who is now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.
A former plus-size model and "big is beautiful" advocate, Renee now realizes the mortal mistakes she has made as her weight swells to 600 pounds and her health deteriorates.
A 24-year-old woman weighs more than 600 pounds and is fighting for her life after a difficult childhood with an abusive stepfather and drug-addicted mother.