Earl Hickey's life has been full of poor choices and mistakes, and upon discovering that he is the holder of a winning lottery ticket, Earl is hit by a car and the ticket blows out of his hand as he lies unconscious in the street. While recovering in the hospital and watching television, Earl has a karmic epiphany, thanks to Carson Daly, who attributes his success to doing good for others. A light bulb goes on in Earl's dim head, and he sets out to right every wrong he has done, starting with a geek he tormented in grade school.
When Joy cons Make-A-Wish to send a celebrity to her trailer, Earl remembers a wish he stole from a dying child and decides it's time to cross him off the list. When he returns to the kid's home, he finds that little Buddy (guest star Seth Green) has exceeded all of the doctors' expectations and is still alive. Buddy asks Earl to produce his movie and suddenly all of Camden County find themselves starring in a high-octane action film. Randy surprises everyone when his acting skills get rave reviews.
Earl and Randy decide it's time to make amends with their childhood neighbors, the Clarks. But when they discover more skeletons in the closet than they had expected, the brothers find themselves needing to sort out some family issues between their mom and dad (Guest Star Beau Bridges). Meanwhile, Joy has duped one-eyed Willy out of his glass eye, and despite Darnell's efforts Willy may never "see" that eye again.
Earl's attempt to give Joy the hot tub she's always wanted backfires and she is forced to stay in a makeshift bubble because of a flesh eating toe infection. While she is out of commission, Earl must fill in as the new Joy. Between gossiping with the ladies at the salon and shopping for meat out of some guy's trunk, Earl learns about the Turner family. This includes the fact that Dodge and Earl Jr. might have a social disorder that causes them to have no friends. Can Earl fix this problem too?
To cross Jerry (guest star Jerry Van Dyke) off of his list, Earl can't just return the RV he stole, mostly because Randy blew it up. Earl and Randy set out to find what might make this grumpy war hero happy, and accidentally turn him into a 75-year-old killing machine. Elsewhere, Joy and Darnell attempt to turn the legend of a giant pig that lives near the trailer park into a one-of-a-kind, money making sideshow.
Earl wants to make up for sleeping with local stuntman Sweet Johnny's girlfriend, while Joy feels the need to buy a gun.
To cross Randy off his list, Earl takes his brother to cheerleading camp. Once there, the tight cheer pants and their lack of flexibility are not their only problem. They also have to deal with Kimmi Himmler (guest star Jenna Elfman), the camp owner with a deeply scarred face and milky eye - both a result of a badger accident suffered while cheering in high school. When Himmler wants the brothers out of her camp, Earl goes to drastic measure to make sure that Randy's cheerleading dreams will come true. Elsewhere, Joy is hurt when her son Dodge indicates that Catalina is the most beautiful woman in Camden.
When Randy's birthday is coming up, Earl gets him a new car, but it is stolen before he can present it to Randy. Apparently, Earl no longer falls under the code of criminals, that no criminal steals from another one. Now that he is treated as a "civilian", he needs to decide whether to take the matter to the police and become a snitch.
Earl plans a Halloween party for Dodge and Earl Jr, while Catalina's nephew Oscar visits. This poses an opportunity for Randy to become the big brother he always wanted to be.
Suddenly at the top of Earl's list a life-or-death item appears right after a new mysterious man moves in next door. Meanwhile, a science fair has Joy all worked up to the point of obsession. She' so fixated on winning the fair so she can buy something special with the prize money.
Earl remembers his first wedding anniversary and the events that finally lead to their break up, involving Earl's cousin Blake and an invasion of killer bees.
Earl loses his list while tornado's hit Camden County. Meanwhile, Randy thinks he's invincible after a wild boat ride and contemplates how he should use his new found power. Elsewhere, who's the smartest , Joy or Darnell? that's what this weeks argument is about and Catalina and Patty have a religious awakening.
Earl remembers a list item he crossed off while reading to the children of Camden County. While going down memory lane, Earl recalls that his old friend Raynard kept company with a raccoon while living in the great outdoors.
Earl discovers that Joy has continued a holiday scam they started years before, and has expanded the scam to include her friends.
A young Earl gets his heart broken by the babysitter and swears revenge on her and her boyfriend. Now, Earl is older and wiser, so he decides to cross them off his list, but it may have terrible repercussions for Randy. Meanwhile, Joy loses Darnell's pet turtle
Joy steals Randy's audition for Erik Estrada's reality show "Estrada or Nada", but her public appearance has consequences for Darnell.
In the aftermath of having his cover blown, Darnell must pack up and leave Camden. Meanwhile, Earl, Randy and Catalina discover a devastating truth within the post office.
When Randy loses his winning lottery ticket, he assumes the event to be a message from Karma, so he starts a list of his own. Meanwhile, Joy is not happy with her cover identity of the witness protection program.
When Mr. Turtle returns back to Earl, he wants to bring him back to Darnell. Meanwhile, Joy and Darnell have to adapt to a new lifestyle of their cover identities.
Danny Glover guest stars as Darnell's father who comes looking for him in Camden only to raise Earl and Randy's suspicions. However, a family reunion leads to father and son partaking in one last undercover mission.
Earl works on a list item that has to do with Chaz Dalton, his childhood hero. Meanwhile, Darnell tries to help Joy make friends using the internet.
Earl works on a list item that deals with a crazy witch lady. Meanwhile, Joy wants to show Darnell her good side.
Earl helps Randy find his first love, Pinky.
Randy busts into the motel room, demanding that Earl drive to Joy's and punch her in the face. Over time, Randy has invested lots of time and money in the Crab Shack's claw machine, but every time he wins a cute stuffed animal, Joy bullies him into giving it to her. This last time he won a fancy bird dressed up for a wedding and the loss has put Randy over the edge. Earl points out that Randy is 32 years old, and it's time he learned to stick up for himself - Earl's not going to protect him anymore.
Earl tests the faith of a former gangbanger-turned-born-again reverend, whom he's wronged many, many times.
News show "Inside Probe" investigates the disappearance of the Crab Shack owner. After eight years the show airs on TV, and several Camden residents become murder suspects.
The mystery of the disappearance of the former Crab Shack owner is finally resolved.
When Dodge (Louis T. Moyle) tells Joy (Jaime Pressly) he doesn't want Darnell (Eddie Steeples) to speak at career day, she enlists Earl (Jason Lee) to pretend to be his father. Things don't go well and Earl realizes Dodge needs to know his real dad. Despite Joy's protests, Earl enlists Randy (Ethan Suplee) and Catalina (Nadine Velazquez) to help him hunt down the deadbeat dad, but what they discover is worse than they could have imagined.
Earl is offered a deal to receive a lesser sentence if he can resolve problems between rival gangs. But, he finds the task harder than he expected. Meanwhile, Randy looks for ways to join Earl in prison.
Joy visits Earl in prison and they are surprised to meet an old friend who is also in prison. The three reminisce about their past and how they met.
Earl is given an assignment after attending a prison class which focuses on creative writing: to write a story. Soon Earl realises that writing is harder than he thought.
It's conjugal visiting day at the prison and since no one is visiting Earl, Frank wants Earl to explain to his girlfriend why he cannot see her today. Things don't go as planned and Frank's girlfriend dumps him because of Earl. Earl is blames himself and vows to get them back together.
The Warden ask Earl to make a skit called 'scared straight' that will stop kids from committing crimes and stay out of jail. Meanwhile, Randy uses his authority to make Earl's life difficult in prison.
Joy enlists the help of Darnell to expediate the baby's birth. Meanwhile, Frank escapes from prison when Randy takes the convicts out for ice cream. Elsewhere, Catalina baby-sits Dodge and Earl Jr.
Earl helps the Warden solve another jail house problem between an inmate and his victims. Later Earl realizes that planning a prom for the inmates might deplete his lottery winnings.
When Earl finds out that the Warden has destroyed all the certificates that would grant him early release from prison, he seeks the help of his friends to escape.
Earl is having difficulty re-adjusting to life on the outside. He returns to his old ways after he encounters Ralph. Randy plans an intervention for Earl on Christmas morning.
While Earl is still in a coma, Randy starts to believe that he can help Earl get better by crossing things off the list.
When Randy visits his parents to make up for their ruined vacation, he realizes that he forgot to tell them about Earl's prison sentence and the following coma at all. A flashback takes us back to when Earl and Randy ruined their parents vacation due to a stolen duffel bag full of weed.
When the hospital wants to get rid of Earl, Randy decides to take care of his brother by himself. But instead of working on the list for Earl, he uses Earl's help to cross things off in order to help him get better.
When Earl finally wakes up from his coma, he believes in Karma again and considers Billie his soul mate.
Inspired by Earl, Billie starts a list of her own and when Earl is getting annoyed by Billie's little habits, he decides to focus on working on the list instead. He picks a task that is on both of their lists, atones for the injury of a champion grocery-bagger and discovers a unique talent of his own. But Earl soon finds out that they have different ways of interpreting Karma.
When Joy and Darnell get into an argument over her surprise birthday, Earl jumps at the opportunity to cross off number 183 on his list “Never took Joy’s side”. Meanwhile Joy runs into various problems after trying to return a television set she recently purchased.
In order to help a friend Earl has to raise a lot of money. He goes to Richard Chubby (Burt Reynolds), owner of Club Chubby a local strip club. He agrees to loan Earl the money if Earl can convince his most popular dancer to come back and work for him.
Earl decides to cross off number ninety-one on his list "Made fun of Maggie Lester for having a moustache." Earl and Randy visit Maggie who is now working for a carnival as "The Amazing Bearded Woman" meanwhile Joy has a run in with the law.
Earl scratches number 56 off his list when he must return a prize winning cat back to its owner after sabotaging a cat show in Joy's favor. Meanwhile Randy forms an attraction with the cat’s owner.
Earl tries to make amends with Tom (number 50), the older man they let be the lead singer in his band but then kicked out before their first performance. While trying to arrange a reunion show Earl must also deal with Number 51, "Slept with Ralph's mom."
Catalina helps Earl cross off No. 75 on his list "Used a mailbox as a trash can" This leads to the discovery of two undelivered letters one is a declaration of a man's love the other reveals Darnell's secret.
In the middle of a heat wave, Earl decides to cross number 26 off his list "Robbed a Stoner Blind." To accomplish this task Earl and Randy find Woody the stoner and must live an environmentally conscious life in the commune with Woody for a week.
Earl tackles number 146 on his list. He decides to make 274 bologna sandwiches for Kenny because he stole them from him in school when they were kids. While delivering the sandwiches, Earl moves onto a new mission, to teach Kenny how to gamble but has trouble stopping. Joy goes to group therapy for her anger management issues.
It's a trip down memory lane for Earl, Randy, Joy, Darnell and the Crab Shack regulars when they remember their fifteen minutes of fame watching a 2003 repeat of the TV show "Cops," which was filmed in Camden County.
In classic whodunit fashion, Earl must determine who took his stolen "treasure" so he can cross it off his list. Joy, Darnell and Randy all give their own version of what happened to the buried treasure.
Earl attempts to figure out how to make amends to a dead guy that he once locked in a truck. Meanwhile, newlyweds Randy and Catalina go hunting for an apartment.
Earl goes for #44 on his list trying to help Pierre, a French foreign exchange student, he made fun of when they went to school together. Earl flies him back to the US and he tries to hook Pierre up with a girl he had a crush on as a child. Meanwhile, newlyweds Randy and Catalina find their marriage changes in ways they would never imagine.
Earl takes on number 101 on his list, "Stole a girl's identity." The girl turns out to be Joy's half-sister that she never knew about and the one person that could possibly help her get sympathy from the jury. The problem, Joy and Liberty are enemies.
Earl wants to use his birthday to look back on all the good he's done over the past year, but at his party, everyone seems to want to talk about his past misdeeds instead.
With Joy now pregnant again, Earl looks back on her pregnancy during their marriage, and how his father was responsible for one of his first truly good deeds.
As Earl and Randy work to cross No. 29 on the list "Harassed A Reporter," Randy gets tired of being in his brother's shadow. In an attempt to distance himself from his brother, Randy realizes the true power of karma and the media.
After Richard Chubby dies, Little Chubby comes to town to take over the family business. While Earl tries to cross an item off his list he learns the true meaning of sacrifice.
Earl tries to apply for a credit card but is declined because he doesn't have a job or a proper place to live, so he goes back to school to receive a diploma, where he realizes how hard it is for teachers to put up with badly behaved kids - just like the one he used to be.
Things are finally looking up for Earl with a GED, a job, a new apartment and love interest however it may all come crashing down during Joy's trial date. Earl's shocking testimony could help Joy but at what cost?
Earl decides to cross off "made a kid scared of the boogeyman" from his list. Earl soon discovers just what kind of lasting affect he had on the little boy.