The crew adjusts to its new studio next to Dr. Oz's; the network sends a new staff member, Davis Maxfield, to do the exact same job as Staci; Davis tells Staci to bump actress Julianna Margulies in favor of a YouTube "unboxing'' star.
Alec and Hilaria Baldwin go out of their way to be empathetic when Staci reveals she had a minor cancerous mole removed; Staci confuses their kindness as sexual interest and propositions them for a threesome.
Staci is caught being a horrible person by Juju Chang's hidden camera show; desperate to prove she's a good person, Staci gets herself in too deep when Brooke Shields pressures her and Kelly Rutherford to take part in a dangerous drinking game.
Actress Julianne Moore shadows Staci to prepare for a role in an independent film; Staci goes on an awkward lunch date with Donny Deutsch; Todd consults Barbara Corcoran and Dr. Oz about donating his body fat to Jimmy for a cosmetic procedure.
Jesse Tyler Ferguson brings his guru/cult leader to the Nightcap With Jimmy set, and arrives at the studio only to find his spiritual guide is not on the security list.
Davis dupes Jimmy's nemesis, Cedric the Entertainer, into coming on the show.
Debra Messing fills in at the last minute and gets too close for Staci's comfort,arranging a "girls spa day" for the two in her dressing room. Davis has his hands full with Brendan Fraser, who wants to try his hand at musical comedy and debut a very offensive song on Nightcap.
TV's favorite dad Bob Saget only wants to talk about his obsession with a Japanese collectible toy; comic Carrot Top convinces Todd to capitalize on an unfortunate nickname earned after an on-air flub.
There's more chaos backstage than normal when Jimmy's new girlfriend Christie Brinkley demands he quit Nightcap. Bethenny Frankel is saving her voice for a speaking engagement and forces Penny to do her dirty work. David Hasselhoff spends the day telling embarrassing stories about his nephew, Nightcap's own hair and makeup guru, Marcus.
Staci pitches a movie to director J.J. Abrams; Penny begs Staci to save the show; Staci offers up TV show host Rachael Ray as an appealing new love interest for fame-hungry Christie Brinkley; actor Mark Hamill shows up to discuss Staci's new film.
Celebrity publicist Malik needs to find a surrogate for her clients Kelly Ripa and Mark Consuelos; Sarah Jessica Parker revisits an old connection with Staci; Bravo's Andy Cohen stops by to promote his unusual new musical game show.
Gwyneth Paltrow turns out to be a serial thief; Paltrow has a confrontation with fellow guest Jim Norton; Jimmy's dog, Monty, moves into the office; interior decorator Nate Berkus comes to design an office suitable for late-night dog royalty.
A lice outbreak forces the whole staff to be treated, causing Whoopi Goldberg to draw the wrong conclusion about the staff members' treatment hairstyles; booked guest Denis Leary calls in sick, but Staci isn't having it.
Staci faces a difficult task involving guest Michael J. Fox and a stunt with a cannon. Meanwhile, Jim Gaffigan desperately wants to promote his new energy drink on the show.
Tim Gunn stops by unexpectedly, so the staff must juggle guests. Meanwhile, Todd asks Debra Messing to film a video while channeling her old sitcom character; and Randy and Marcus pitch their invention to Mark Cuban.
Jason Biggs acts differently on a return appearance, surprising the staff. Meanwhile, Beth Stern promotes animal adoption by bringing kittens, but trouble arises when one cat disappears.
Staci tries to convince transgender celebrity GiGi Gorgeous to go on a date with Jimmy; Ana pitches her makeup line and wants Stephanie March to be her new spokesperson; Janeane Garofalo is dismayed by Jimmy's sexist sketch.
Chef Mario Batali tries to aid Staci as she struggles through a horrible bout of irritable bowel syndrome; journalist George Stephanopoulos schools Penny on ISIS, an organization she believes is trying to recruit her.
Jimmy wants a biopic made about his life, and he wishes to be portrayed by Paul Rudd. Meanwhile, Wendy Williams strikes up an unexpected bond with someone over wigs.
Staci interviews for an Executive Producer position at Wendy Williams and seriously considers leaving Nightcap. Mariska Hargitay has agreed to be eaten by an anaconda on air, and Todd gets to direct his first shoot starring Rosie Perez—until Joel Schumacher intervenes.