Follows the story of Claire Randall, a married combat nurse from 1945 who is mysteriously swept back in time to 1743, where she is immediately thrown into an unknown world where her life is threatened. When she is forced to marry Jamie Fraser, a chivalrous and romantic young Scottish warrior, a passionate relationship is ignited that tears Claire's heart between two vastly different men in two irreconcilable lives.
Returning to her own time, Claire must reconcile her future with the life she left behind. Shifting back to the 18th century, Jamie, Claire and Murtagh arrive in France, but learn that Paris presents its own challenges.
Life in Paris is not without trials as Jamie struggles to triumph over his past. A fortunate meeting with Prince Charles presents opportunities, while the Duke of Sandringham's presence brings complications.
Jamie’s time is dominated by political machinations, while Claire finds solace in her healing skills.
Claire and Jamie throw an elaborate dinner party intended to derail investors in Prince Charles’ war effort.
Claire and Jamie reunite and attempt to extinguish fires until Claire makes an unexpected change of course; Jamie and Claire's relationship is tested when the past rears its ugly head.
Jamie and Claire use Claire's medical knowledge to come up with a scheme to stop a deal which could fill the war chest; Claire learns Jamie has gone back on his word.
Doctors at L'Hopital des Anges attempt to save the lives of Claire and her unborn baby; King Louis asks Claire to judge two men accused of engaging in the dark arts.
Claire and Jamie attempt to elicit support from Jamie's grandsire, Lord Lovat; Colum MacKenzie arrives with plans of his own; Lord Lovat makes moves to advance his own interests.
Claire and Jamie reunite with the Lallybroch and MacKenzie men during training; Jamie and Claire wage personal battles; an Englishman arrives in camp with new information.
Jamie uses Claire's knowledge of the future to lead the Jacobite army into battle against the British, while Claire tends to the wounded, a harsh reminder of the cost of war.
Claire and the Highlanders make their way north after the Jacobite leaders decide to stop their march on London. Jamie is included in the group of riders enlisted for Dougal. Claire also joins them.
Jamie works to divert the Jacobite army away from imminent slaughter; Claire tries to provide comfort to a sick Alex Randall; Alex shares an unusual plan to save the mother of his child.
While on her honeymoon, WWII combat nurse Claire Randall is mysteriously transported back to 1743 Scotland, where she is kidnapped by a group of Highlanders - and meets an injured young man named Jamie.
Claire is taken to meet the Laird. As suspicions about her grow, Claire befriends the mysterious Geillis Duncan. When the clan discover her medical skills, Claire goes from guest to prisoner.
Claire decides to use her medical skills to aid her escape from Castle Leoch - with Jamie's help, she tends to an ill child. During an evening's entertainment, a story gives Claire hope for her freedom.
As the Castle prepares for The Gathering, Claire plots her escape. But after a dangerous encounter with a drunken Dougal and an unexpected run-in with Jamie, her plans are dashed.
Claire's unexpected meeting with a British general turns tense when Captain Jack Randall arrives. Claire finds herself alone with Randall - a dangerous man determined to uncover her secrets.
Claire and Jamie are thrown together in marriage, but as their emotional and physical relationship unfolds, deeper feelings arise. Claire is ultimately torn between two men in two very different times.
Frank desperately searches for his missing wife, while Claire tries to come to terms with her new marriage. Claire is faced with an emotional quandry as a life-altering opportunity presents itself.
Jamie and the Highlanders rescue Claire from Black Jack Randall. Back at the castle, politics threaten to tear Clan MacKenzie apart and Jamie's scorned lover, Laoghaire, attempts to win him back.
Jamie hopes the Duke of Sandringham can help remove the price on his head, while Claire works to save an abandoned child.
Claire and Geillis are on trial for witchcraft. Jamie manages to rescue Claire, but not before she discovers a secret about Geillis' past.
Claire and Jamie are reunited and head to his family home, where old animosities between Jamie and his sister, Jenny, are rekindled.
Jamie finds himself between a rock and a hard place when a redcoat deserter from his past resurfaces. Claire tends to a laboring Jenny while Jamie and Ian join The Watch, resulting in devastating consequences. - Whilst Jamie has been gone, sister Jenny and her husband Ian have been paying a gang of ex-militia/highwaymen protection money, food and good tobacco to keep them from the jaws of the Red Coats. Tension is high as Jamie has to assume a 'cousin' of the family so as to hide the fact that he has a price on his head. Unfortunately, someone they have come across recently connects up with the gang - and he knows Jaime and his secret. This rogue has a plan for the gang to rob a rent packet but he also blackmails Jaime to keep his secret - or has he spilled the tale already. Jenny and Claire are busy bringing the latest Fraser into the world - a breech birth.
Claire and Jenny set out to rescue Jamie from his redcoat captors. When Murtagh joins up, they turn to unorthodox tactics to send word to Jamie. When word finally arrives, the news isn't what anyone had hoped.
Jamie awaits his death sentence at Wentworth Prison, while Claire and the Highlanders search for a rescue plan. When Jamie is visited by Black Jack, he realizes there is a fate worse than death.
A desperate plan manages to free Jamie, but his wounds are more than just physical. At a nearby monastery, Claire attempts to save both Jamie's heart and soul, as his mind lingers on the torture.
Claire joins the MacKenzie rent-collecting trip. To her horror, Dougal uses Jamie's scars to gain sympathy for the Jacobite cause. Claire recalls that a defining moment in Scottish history is fast approaching.
After living through the Battle of Culloden, Jamie finds himself at the mercy of unforgiving British victors, until a connection from his past provides his only hope of survival. Meanwhile, a pregnant Claire attempts to adjust to life in the modern world of 1940s Boston – and life with Frank.
Jamie leads a lonely life hidden in a cave until Lallybroch is threatened by redcoats; Claire and Frank struggle to coexist in a marriage haunted by the ghost of Jamie.
In prison, Jamie discovers that an old foe has become the warden – and now has the power to make his life a living hell. Over the years, Claire and Frank both put their best foot forward to share a harmonious marriage, but an uninvited guest shatters this illusion, bringing their differences to light.
While serving as groomsman at the aristocratic estate of Helwater, Jamie is reluctantly pulled into the intrigue of a noble British family. In 1968 Scotland, Claire, Brianna and Roger struggle to trace Jamie's whereabouts in history, leaving Claire to wonder if they will ever find him again.