What if an angel and a demon procreate? What would that offspring be? Would it be holy or demonic or both? Preacher is that tale. The offspring has no body, just a soul. That soul needs a body and chose Jesse Custer. A preacher from Texas with a loss of faith and a drinking problem. The offspring called Genesis bonds with Jesse, giving him the word of God. What he says is done.
Jesse tries to be a "good preacher," unaware that a mysterious duo is after him. Meanwhile, the enigmatic Cowboy is introduced.
Cassidy helps Jesse explore his newfound power; based on new information, Tulip tries to convince Jesse to seek revenge.
Jesse makes Quincannon a bet he can't refuse; and Cassidy works to fend off the angels. Meanwhile, Tulip tries to bring justice to Annville.
Following his stunt, Jesse becomes Annville's newest rock star; Tulip and Cassidy connect; the Cowboy makes a decision.
Jesse finally comes face to face with Deblanc and Fiore and learns about the mysterious entity that has taken over his body.
Jesse's actions alienate and endanger those closest to him as we glimpse into his past and finally learn the root of all of his guilt.
Jesse protects his church in a vicious gun battle against Quincannon and the Meat Men; Tulip hopes to save a friend.
Jesse's in the wind while those close to him face life-changing decisions; the Cowboy comes back to Ratwater seeking his revenge.
Jesse hopes to follow through on his promise to obtain answers from heaven; the entire town waits with bated breath.
Jesse struggles to escape a past that is slowly catching up to him. A mysterious entity comes to earth, leaving a wave of destruction in its wake.
Jesse, Tulip, and Cassidy begin the search to find God. The trio realize they are being followed by a killer cowboy from Hell.
Jesse, Tulip, and Cassidy track a lead from Heaven. The trio tries to find out who the Cowboy is and why he's attempting to kill them.
Jesse, Tulip, and Cassidy get a tip that God may be in New Orleans. Tulip is hiding a secret and their stop in New Orleans risks exposing her.
Jesse pursues a lead and dives deeper into his search for God with Cassidy and we discover more about Tulip's secret past.
After learning about Tulip's secret relationship, we revisit Jesse and Tulip's rocky past and see a darker side of Jesse.
The Saint corners the trio. Jesse makes a deal with the killer Cowboy. Jesse races to save Tulip and Cassidy.
Tulip confronts her near-death experience. Denis asks Cassidy for a favor. Jesse questions the price of saving Cassidy and Tulip.
Jesse investigates a fresh clue about God. Tulip makes friends with a new neighbor, and we get a glimpse into Cassidy's past relationship with Denis.
Jesse gets a much-needed breakthrough on his search for God. Tulip continues to spiral and Cassidy makes a life-altering decision for Denis.
Jesse connects with an unlikely source and learns more about God's whereabouts. Tulip can't forgive Jesse when she finds out he's been lying to her.
The mission begins to alienate Tulip and Cassidy. Tulip receives advice about her relationship with Jesse. Cassidy begins to doubt Denis.
Jesse, Tulip and Cassidy hit a bump in the road and decide to leave New Orleans. An old foe resurfaces and causes a change of plans.