After damaging a national monument, the League of Freedom gets called before Congress and investigated by military accountant Sgt. Agony. Black Saturn embarks on a showdown with his nemesis, the Groaner. Robobot investigates his origins while the team struggles to solve its budget crisis.
When Titanium Rex’s old colleague Omega Ted is found dead, the League of Freedom must care for his orphaned Omega Pets. While Jewbot, Cooch, and Brad cope with pet ownership and a jealous Black Saturn, Rex and American Ranger investigate Ted’s mysterious death.
After an embarrassing encounter with the interstellar super villain Blazar (Ron Perlman, Hellboy), Titanium Rex resolves to salvage his public image. Black Saturn launches an investigation to find out who has been eating his food while Brad tries to take advantage of Cooch being in heat.
American Ranger’s former sidekick and current Secretary of Defense Kid Victory (Scott Thompson, Kids in the Hall) joins the League for dinner at the mansion. Rex tries to secure more funding while Ranger struggles with Kid Victory’s lifestyle and the rest of the League goes grocery shopping.
When Sgt. Agony discovers that Cooch is illiterate, the League of Freedom bands together to help her study for her GED. American Ranger embarks on a road trip in search of the American dream and Jewbot yearns to be an inspirational influence.
Titanium Rex is stunned when Lex Lightning shows up on his doorstep claiming to be his illegitimate daughter. While Rex grapples with fatherhood the smitten American Ranger, Black Saturn, and Brad start a rock band to impress Lex.
Black Saturn gets into the dating scene after a cat burglar breaks his heart and Rex, Ranger, and Brad try a sadistic new workout regimen with personal trainer Johnny Rabdo. Meanwhile Lex tries to get on Cooch’s good side as Jewbot struggles with gender identity.
Brad's past catches up with him while the League looks for any escape from Titanium Rex's game night. American Ranger discovers the joys of the Internet.
When Black Saturn is cut off financially, he uses Lex in his bid to gain an allowance. Jewbot explores the life of a caregiver and Titanium Rex attempts to cancel his cable subscription. Guest starring Anton Yelchin (Star Trek).
Rex and Ranger’s peaceful camping trip does not go as planned when the rest of the League tags along. Rex waits for the perfect time to talk to reveal a dark secret to Ranger while Saturn hides his relationship with Lex. Jewbot goes offline and Cooch learns that she does not do well in nature.
The League of Freedom prepares for the worst as the resourceful Dr. Devizo plans his escape from the mansion’s underground prison. Rex attempts to match wits with Devizo while Black Saturn goes undercover and American Ranger seeks retribution for Gloria’s betrayal.
Billionaire defense contractor Ivan Whiff tries to lure Lex away from the League. Meanwhile, Jewbot administers routine physicals for the League, causing Ranger to disavow modern medicine and Brad to discover he may be allergic to Cooch.
In the Season 1 finale, Dr. Devizo orchestrates a jailbreak of the League's most dangerous villains.
After helping the League of Freedom save the world, Dr. Devizo and his team of villains move into the Mansion as bona fide heroes. The team struggles with their new roommates as Robobot travels across the country in search of the elusive Swine Kampf.
When Lex starts dating the vigilante anti-hero Max Penalizer, Titanium Rex and Dr. Devizo team up to break them up. As the villains of the mansion set their eyes on bedding Cooch, Robobot learns the dangers of telling humans little white lies.
In the Season 2 premiere, the League of Freedom is still reeling following the destruction of the SuperMansion, as all the villains roam freely throughout Storm City. Meanwhile, American Ranger helps Cooch cope with Brad's death; and Titanium Rex and Jewbot team up to prevent a cult from leaking sensitive intel.
Titanium Rex tries to persuade an old friend into joining the League in hopes of restoring their tarnished reputation. Meanwhile, Black Saturn introduces Jewbot to fraternity life; and the rest of the League experience college for themselves.
Portia Jones makes plans to open a pizzeria and arcade based on the League in hopes of restoring their reputation. Meanwhile, Jewbot learns about his past and undergoes an existential crisis.
J.K. Simmons follows Titanium Rex around in hopes of playing him in a movie about the League. Meanwhile, the recently-escaped villains form their own group, the Injustice Club.
Titanium Rex and Black Saturn have something to say about American Ranger's undeniable attraction for Zenith.
The League is called upon to stop an enormous space alien from obliterating planet Earth. With the help of NASA, the League embarks on their mission, but Rex and team prove dangerously ill-suited for the stresses of space travel.
After Black Saturn resigns from the League, he takes on his first solo case: a string of kidnappings, all women who used to model for a famed ’70s photographer. As Saturn tries to track down the photog, Titanium Rex’s old secret identity comes back to haunt him.
After years of searching, Rex’s brother, Titanium Dax (Dax Shepard), becomes the second Subtopian ever to breach Earth’s surface. He and his rock monster slave, Liplor, are thrilled to find Rex alive, but their reunion is soured when Dax threatens to reveal a secret about Rex’s origins.
To protect the League, Rex has gone into hiding, working as a lumberjack far from civilization. While Rex tries to cope with his new identity as a regular joe, Robobot attempts to get a downtrodden League of Freedom back together to take on a dire threat to Storm City.