Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Alone in the world and unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.
Shaun’s proposed treatment for a homeless patient puts him and Dr. Kalu in Dr. Andrews’ crosshairs. Claire tries to overcome Dr. Melendez’s reluctance to do a risky heart operation. Dr. Glassman faces a difficult decision about his health.
As Shaun pushes back against Dr. Melendez in order to treat a gravely ill hospital janitor, Dr. Lim risks a lawsuit to repair a teenage girl’s ritual circumcision. Dr. Glassman exercises demanding oversight in choosing a doctor for his brain surgery.
Dr. Melendez, Dr. Brown and Dr. Park have given a young married couple two choices about their future: save the wife’s life or their future ability to start a family. Meanwhile, when Dr. Lim has to take care of some personal business, she leaves oversight of the emergency room to Dr. Murphy and Dr. Reznick; and Dr. Glassman’s post-op recovery leaves him struggling to get the rest he needs for recovery and also confronting his relationship with his daughter.
Shaun recalls his own past to help an intellectually disabled teenager face separation from his mother, while Claire is put between an injured teenage rock climber and her worried parents. Meanwhile, Glassman’s post-op hallucinations force him to confront a personal tragedy.
When a patient suffering from anorexia can’t gain the necessary weight needed to survive heart surgery, Claire suggests they perform an experimental surgery which Melendez strongly opposes. Shaun worries Glassman’s refusal to walk the hospital floor will keep him from being discharged and tries to persuade him to ambulate. Meanwhile, Shaun and Lea change the terms of their current relationship.
Morgan and Shaun’s indecision on how to treat a young violinist who visits the ER with an infected finger could affect her future in more ways than one. Meanwhile, Lim, Claire and Park can’t figure out if their young patient is really ill or looking for attention.
Dr. Shaun Murphy and Dr. Morgan Reznick must contend with two brothers who are bargaining over life and death. Meanwhile, Dr. Claire Brown’s friend who is dying of cancer asks her for something she doesn’t think she can give her; and Dr. Aaron Glassman is dealing with the effects of his treatment.
Dr. Shaun Murphy, Dr. Audrey Lim and Dr. Claire Brown's E.R. patient is forced to reveal a secret to her husband after their treatment caused a complication. Meanwhile, Dr. Neil Melendez, Dr. Morgan Reznick, and Dr. Alex Park struggle with a patient whose parents don't believe in vaccinations.
Dr. Neil Melendez, Dr. Morgan Reznick, and Dr. Claire Brown grapple with a patient's wish to perform an operation that would keep him from acting on his pedophilic urges. Dr. Shaun Murphy learns a lesson in empathy.
Dr. Shaun Murphy and Dr. Audrey Lim treat two patients who collapse at the local airport and whose symptoms point to an infection that may become airborne. The staff races to contain the infection before it spreads to the rest of the patients in the ER.
The hospital is still in quarantine as Dr. Murphy continues to be overwhelmed by the chaos and noise in the emergency room; Dr. Reznick struggles to keep her patients alive, and Dr. Lim fights for her life.
In the aftermath of the quarantine, the staff tries to return to their normal routines. Meanwhile, as Dr. Lim recovers from the virus, she and Dr. Melendez navigate their new personal and working relationship, while Dr. Murphy and Dr. Glassman visit Lea.
Dr. Shaun Murphy, Dr. Morgan Reznick and Dr. Audrey Lim treat a woman with autism and a delicate brain condition while navigating the complicated relationship she has with her roommate, who is also on the spectrum. Meanwhile, Lea and Shaun are still figuring out their friendship and roommate status.
Dr. Andrews tries to convince a grieving family to donate their teenage daughter’s face to another young girl whose face was horribly disfigured in an accident.
Shaun’s blunt honesty with a distraught mother of a critically ill newborn baby causes the new chief of Surgery to question keeping him on as a resident.
The new chief of surgery, Dr. Jackson Han, believes Dr. Shaun Murphy is a liability more than an asset and works to keep him out of the operating room permanently.
Dr. Shaun Murphy is desperate to join the team on a dangerous procedure involving a patient's tumor removal. However, having been removed by Dr. Jackson Han from the surgery team, he must use his talents to help figure out the cause of an infant's injuries.
As a barroom fight sends Dr. Shaun Murphy to seek treatment at St. Bonaventure’s, Dr. Alex Park and Dr. Audrey Lim disagree over an elderly woman’s post-operative symptoms. Meanwhile, Dr. Neil Melendez and Dr. Lim make their romance public, and Dr. Aaron Glassman continues to pursue a relationship with a good friend.
Dr. Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join the prestigious St. Bonaventure hospital’s surgical unit. Alone in the world and unable to personally connect with those around him, his only advocate, Dr. Aaron Glassman, challenges the skepticism and prejudices of the hospital’s board and staff when he brings him in to join the team. Shaun will need to work harder than he ever has before, as he navigates his new environment and relationships to prove to his colleagues that his extraordinary medical gifts will save lives.
Dr. Shaun Murphy’s attention to detail complicates his first day at St. Bonaventure Hospital. Meanwhile, Dr. Claire Browne learns a valuable lesson about honesty when confronted with a difficult diagnosis for her patient.
Dr. Neil Melendez and Dr. Jared Kalu discover their patient isn’t being completely honest with them which may cost him his chance at a life-saving surgery. Meanwhile, Dr. Claire Browne must learn to communicate with Dr. Shaun Murphy as they race back to St. Bonaventure Hospital with a donated organ.
Dr. Neil Melendez and the team have to wade through legal waters when a husband and wife have to make a life-changing decision about their unborn child. Meanwhile, Dr. Shaun Murphy struggles to adjust to his new environment at home and makes a huge step forward with his colleagues.
While in the exam area of St. Bonaventure Hospital, Dr. Shaun Murphy encounters a young patient who looks eerily similar to his deceased brother, Steve. After discovering his parents have hidden his diagnosis from him, Shaun struggles to understand why he doesn’t deserve to hear the truth about his own health. Meanwhile, the team can’t figure out what keeps triggering their patients’ increasingly severe allergic reactions and races to find the cause before the next one kills another patient.
Dr. Shaun Murphy and Dr. Claire Browne devise an experimental procedure that can save the leg and life of a young groom, that is if his bride-to-be and parents can learn to work together. Meanwhile, Jared struggles to emotionally connect with his patient whose scars may prove too deep to overcome.
Dr. Shaun Murphy has to confront prejudice from an unlikely source when he takes on the case of a patient with autism, and Dr. Jared Kalu has to learn to accept his limitations as a surgeon.
During a robbery at the grocery mart Dr. Shaun Murphy is shopping at, his communication limitations puts lives at risk. Meanwhile, after Shaun’s traumatic day, Dr. Aaron Glassman worries that he isn’t doing enough to help Shaun.
As part of St. Bonaventure hospital’s international humanitarian program, the team takes on the case of a young boy from the Congo who has severe congenital heart anomalies. Dr. Neil Melendez has doubts about the safety of the procedure, while Dr. Shaun Murphy works out the best course of action. Meanwhile, Murphy’s latest encounter with his neighbor Lea has him confused.
Members of the hospital’s surgical team are initially impressed with a charming young doctor, but his true character puts one of them in an awkward position at work. Meanwhile, Dr. Glassman feels Dr. Shaun Murphy needs a little more support with his personal life and suggests he meet with a therapist. However, Shaun is determined to show him that he can do it on his own.
Dr. Marcus Andrews enlists Dr. Neil Melendez on a very sensitive kidney transplant between a pair of twins; Dr. Shaun Murphy decides to take an impromptu trip with his friend Lea and leave his problems behind.
The twins suffer complications from their surgery forcing the team to make a life-changing decision. Shaun returns to the hospital after his trip with Lea and decides he needs a more permanent change – and gives Dr. Glassman his two weeks’ notice.
Shaun suspects his patient is lying about the reason for her injury and makes a controversial assumption about her motives. Dr. Melendez’s personal life could be affecting his work and, ultimately, his patients' lives.
Shaun is surprised to learn that his young cancer patient identifies as a girl while being biologically male. He must quickly learn to understand his patient, her medical needs and how to work with her family, who all feel they know what is best for her.
Dr. Shaun Murphy's teenage patient has been confined to her home her entire life due to a rare heart condition. Despite her condition, she has cultivated a large group of friends online and hopes that the surgical team can find a way to give her the life she has always dreamed of having. Meanwhile, a young patient's perfectly matched organ donor is causing a moral dilemma for the parents and the patient.
When the team treats a patient who has to decide between a dangerous surgery that could change his life or remain the same, he asks Dr. Shaun Murphy what he would if he had that same choice.
Dr. Shaun Murphy questions the need for an elective surgery that will allow his young patient to smile for the first time. Meanwhile, Dr. Claire Brown and Dr. Morgan Reznick discover that their patient lied about her identity.
The team at St. Bonaventure needs to quickly discover the truth behind a young college student’s unexplained injuries before his condition worsens. Meanwhile, after losing his most prized possession, Shaun’s distraction during a surgical procedure may end up risking more than just his job.
Following what he believes was a disastrous first date with Carly, Dr. Shaun Murphy proposes a radical surgery to save a newlywed woman’s life. Meanwhile, after the new chief of surgery, Dr. Audrey Lim, announces that the residents can lead surgeries, Dr. Morgan Reznick and Dr. Alex Park compete for the chance to operate on an elderly patient who has been diagnosed with cancer.
As Dr. Marcus Andrews vows to help a good Samaritan who was injured while stopping a sexual assault, Dr. Audrey Lim faces a difficult decision when a young patient’s parents suspect that Dr. Neil Melendez made a mistake. Meanwhile, Dr. Shaun Murphy fields advice following his disastrous date with Dr. Carly Lever; and Dr. Claire Browne gets a surprise visit from her mother.
Dr. Claire Browne faces complications at home and work as she prepares to lead her first surgery. Meanwhile, a sports fishing accident challenges the rest of the staff as they look to treat the fisherman’s injuries without damaging his prize catch.
As a conspiracy theorist questions Dr. Neil Melendez’s of his liver damage, Dr. Claire Brown treats a woman whose inability to feel pain is threatening both her marriage and her life. Meanwhile, Dr. Shaun Murphy and Dr. Aaron Glassman each face crises in their romantic relationships.
Dr. Shaun Murphy has been assigned his first surgery by Dr. Audrey Lim. However, Dr. Marcus Andrews questions whether he is really ready. Meanwhile, as Dr. Claire Brown continues to avoid her complicated emotions about her mother, she and Dr. Morgan Reznick have a patient whose diagnosis has them doubting his story.
While performing his first solo surgery, Dr. Shaun Murphy alienates a nurse, which puts his residency in jeopardy. Also in this episode, Dr. Neil Melendez disagrees with Dr. Audrey Lim on a risky surgery, and Dr. Claire Brown spirals into self-destructive behaviors, causing negative ramifications in the workplace.
Dr. Shaun Murphy’s unique ability to relate to a patient isolated by an immune deficiency yields an unexpected result. Meanwhile, Dr. Claire Browne, Dr. Morgan Reznick and Dr. Marcus Andrews treat a 12-year-old patient who is about to become blind, and tension builds between Dr. Neil Melendez and Dr. Audrey Lim.
Carly’s attempts at increasing her intimacy with Shaun are becoming more of a frustration than either of them expected. Lim and Melendez struggle in their relationship as they work to separate their work from their personal life.
Shaun is ready for the next step in his relationship with Carly. However, he continues to struggle as they grow closer and more intimate, and is dealt some troubling news about a deeply personal issue. A young patient must decide on a treatment that could save her life or possibly destroy her marriage.
Shaun visits his father on his deathbed and the family reunion reveals unexpected results. Melendez, Park, Reznick and Claire treat an injured star NFL player with severe spinal damage. Claire addresses her mental health.
Following his father’s death, Shaun must deal with the effects his intimacy with Lea will have on his relationship with Carly. The team operates on a patient who is refusing all anaesthesia during surgery for fear of relapsing.
Lim, Shaun and Reznick treat a 25-year-old runner suffering from severe swelling; but when things take a turn for the worse, Shaun enlists the help of Carly. Park, Claire and Melendez treat two 16-year-old cancer patients who are dating. Shaun and Carly work toward intimacy.
Shaun and Reznik grapple with a terminal cancer patient who is determined to live the last few months of his life without inhibition. Reznik must confront her relationship with her mother when she comes in for a third opinion from Glassman. Shaun and Carly's relationship reaches a new level of intimacy.
After Shaun treats a patient who is a social influencer, he deals with unwanted attention. The team treats a woman who is in abdominal distress after an at-home faecal transplant Carly's efforts to separate Shaun from Lea are challenged.