The series profiles unsolved and ongoing high-profile crime stories as told by witnesses and law enforcement officials, along with re-enactments of how the events happened. A picture of the person or persons involved are shown along with a number to call if they have any information or leads on the subject featured on the program.
Profiled: Christopher Ponce, a fugitive accused of DUI manslaughter; and David Burgert, a militia leader who went on the lam after provoking a shootout with law enforcement.
Season 3 begins with John Walsh offering updates on fugitives still at large and those who have been captured, resulting in closed cases.
Authorities in Texas are searching for William Joseph Greer who confessed to having murdered his girlfriend Tammy Esquivel, a divorced stripper in 2006, but has managed to stay one step ahead of the law.
Accounts of a Nebraskan alleged serial rapist and two members of the L.A. Boyz gang, brothers, who may be hiding in Mexico.
A search for Elby Hars, who allegedly abused a young girl in Columbia, S.C.; a hunt for Eugene Palmer, who allegedly shot and killed his daughter-in-law.
Police hunt Robert William Fisher who is wanted for the 2001 murders of his wife Mary and their two children; police pursue Honolulu couple John and Julieanne Dimitrion who are wanted for mortgage fraud.
Authorities in Harris County, Texas are desperate to find Alfonso Diaz-Juarez, a convicted pimp, child molester and sexual predator, known for profiting from prostitution and sex trade trafficking.
An alleged rapist forces his 17-year-old victim to marry him, then imprisons her in a psychological cage for seven years.
A serial child molester preys on young women in his own family for two generations, then vanishes just before his 12-year-old daughter is about testify at his trial; a volatile ladies' man with a history of violence allegedly murders his sister.
A Santería priest allegedly murders his lover, rapes a minor during a "healing" ritual and molests his step-daughter, all while hiding behind the cloak of his religion.
A family man allegedly rapes his stepdaughter for five years before she comes forward with the truth; two coworkers and roommates become close friends, but soon greed and desperation drives one of them to allegedly commit murder.
Two old friends reconnect on Facebook and become lovers, but the romance ends with one dead and one on the run; a random encounter during a night of fun with a group of friends leaves two of them dead.
Maria Cabrera is accused of kidnapping her own child while in the middle of a custody dispute with the boy's father; more than 20 years after a young mother was raped and murdered while at work, police identify a suspect in her case.
Ty and Tisa Yiyara founded a progressive urban school but went on the run after they allegedly were caught having sex with a student; a construction worker in New York is accused of killing a popular young man.