Hank and Dean Venture, with their father Doctor Venture and faithful bodyguard Brock Samson, go on wild adventures facing megalomaniacs, zombies, and suspicious ninjas, all for the glory of adventure. Or something like that.
Dr. Venture learns that a life without an arch enemy is not fulfilling.
Billy Quizboy recovers the memories of his former life as a failed TV Quizboy, the loss of his hand and eye in a dogfight, his recruitment into the OSI, and his first mission as a spy.
With the Monarch busy settling into his new home with his wife, a new villain arises to arch Dr. Venture.
Dr. Venture decides to raise money by running a Day Camp for Boy Adventurers. Things don't go quite as planned when a giant ape gets loose, Action Johnny loses it, Sgt. Hatred arrives for an unscheduled bush burning, Hank gets a new friend who pushes Brock's buttons, and the Monarch sends the Moppets in to spy.
Team Venture meets Team Quymn, led by Dr. Tara Quymn, Dr. Venture's childhood sweetheart. Her two twin daughters and manly bodyguard seem oddly familiar, but the two teams must join forces to battle a dreaded were-o-dile: half man, half crocodile.
Brock and Dr. Venture stumble into a hidden state-of-the-art fallout shelter beneath the Venture compound, while Hank and Dean call in Dr. Orpheus to summon the Order of the Triad and help them out.
The Monarch gets word that Dr. Venture and Brock are at a science conference, and decides to launch an attack on the Venture compound.
Dr. Jonas Venture Jr. builds a museum in honor of his "father," and invites all of Jonas Sr.'s old friends and enemies to the grand opening.
The Monarch leads an attack on his new arch-nemesis, Dr. Jonas Venture Jr., at his base on Spider Skull Island.
Billy Quizboy has spent thirty years trying to decipher a series of cryptic clues hidden in Rusty Venture Cartoon Show episodes. Finally the solution to the mystery is at hand, but the answer forces Brock to discover what his true orders are.
The OSI has put a termination contract on Brock's head, and three top assassins plan to collect. Meanwhile, the Monarch and Sgt. Hatred battle to see who will be Dr. Venture's arch.
Continuing after the prior episode, General Traceter (alluded to in Season 1 during Brock's License exam in Mid-Life Chrysalis) heads a OSI assault team to go after Samson and the Venture Family after the original three assassins fail to do their job. Using ingenuity to save the Venture Family once more, Brock Samson hatched a plan to force OSI and Monarch's Henchmen to fight each other instead of pursuing the family. In the aftermath of the fight, OSI gains victory after one of Monarch's Flight Suits malfunctions and ends up shooting his own minions in friendly fire. After revealing himself being on neither side of the fight, Brock makes a shocking announcement to Thaddeus and General Traceter that would affect the rest of their lives.
Henchman 21 copes with life without 24. Brock and the Venture family are forced to part ways. Discover the final fate of H.E.L.P.eR. And Dean must kill Hitler.
The Monarch decides to settle for cash as the best revenge on Dr. Venture and takes Hank and Dean hostage. However, Hank is rescued by Captain Sunshine, who wants a new boy sidekick to replace his fallen comrade Wonder Boy.
Rusty begins to indoctrinate Dean into his career as a super scientist, not knowing that a deformed and believed aborted Dean clone stalks the compound. The deformed clone's attempt to kill Dean leads to a mix up with Hank thinking that he's killed his brother, while local police prepare to raid the Compound after a UPS delivery man suspects illegal activities going on.
Henchman 21 kidnaps the Venture brothers without The Monarch's knowledge or consent, resulting in Sgt. Hatred having to storm his former hometown of Malice to rescue his charges. We also learn of the recent activities of 21 since the death of 24.
The Guild of Calamitous Intent comes under attack by an insane Phantom Limb, who now goes by the name "Revenge". Meanwhile, Hank and Sergeant Hatred must protect the compound from the Guild's agents. We also learn something very interesting about Dean's birthright.
While Dr. Venture goes into therapy with other boy adventurers, Sgt. Hatred takes Dean and Hank to the movies, only to have a relapse.
After seeing the OutRider, the man who stole his wife, pass through the Second World, Dr. Orpheus is determined to do the same. Meanwhile, Hank takes Dean to the mall to teach him how to talk to girls, and Triana has a life-altering discussion with The Master.
While the Monarch schemes to dispose of Dr. Venture once and for all, Henchman 21 seeks revenge on Brock for the death of 24.
Brock, Hank, and Dean must go on a fantastic voyage into Rusty's brain to find out why he's in a coma. Meanwhile, Henchman 21 demands new henchsuits, but the Monarch is too busy obsessing with his latest purchase, a butter-glider.
Someone is capturing heroes and villains and taking them to a super death camp. The forces of good and evil must join forces to stop their mysterious captor.
Hank opens a detective agency and enters a dark world of sinister crime and shady women.
Dean ends up interning with Professor Impossible, and discovers that his new employer is a member of the Revenge Society.
Dr. Venture is possessed by an entity that attempts to make him commit suicide, and Dr. Orpheus tries to save him.
Conjectural Technologies' newfound success hits a snag when Billy is kidnapped by the same mysterious benefactors who invested in their company, and SPHINX launches an investigation aimed at determining who is behind these dubious financiers.
Team Venture, Conjectural Technologies and the Order of the Triad come together as Dean and Hank prepare to face an obstacle that is more intimidating then anything they have confronted before: a prom to celebrate their "graduating" high school, while Dr. Venture throws out all the stops to bring the twins the best dance $500 can buy. But when things go awry, the greatest battle in Venture history looms as two old enemies - the OSI and SPHINX - clash once again.
The premiere episode finds Team Venture and friends struggling to pick up the pieces of their shattered lives and move on in the wake of Hank and Dean's violent and untimely deaths. While Doc searches for his soul in the far corners of the globe, Dr. Orpheus wallows in guilt, and a mullet-less Brock repairs his beloved Charger, The Monarch plots a daring prison break with the help of his fellow supervillainous inmates.
Aided by Henchman 21, 24, and a ragtag band of roughneck new recruits, the Monarch attempts to rebuild his villainous empire and rekindle his relationship with Dr. Girlfriend. A showdown at the local shopping mall forces his hand, and he struggles to choose between revenge and reconciliation amidst a sea of violence. Meanwhile a wounded Brock falls into the clutches of The Phantom Limb, Hank drives Brock's car, and Dr. Venture gets an eye full.
When Brock is reactivated by the Office of Secret Intelligence to track down a rogue agent, he subcontracts his ex-girlfriend, the malevolently mercenary Molotov Cocktease, to protect the Venture Compound from enemies within and without. Love is in the air! Or is it...murder?
The Phantom Limb and Dr. Girlfriend agree to a civil double date with The Monarch and some girl he met on the internet in order to discuss The Monarch's official re-entry into the Guild of Calamitous Intent. Doc and Brock become the unwitting pawns in a low-grade pissing contest when Phantom Limb's sics the Guild's commandos on the Venture compound to prove his dominance. Can Brock hold off an army? Can Doc escape death and finish watching the worst porno ever?
Baron Ünderbheit captures Team Venture when the X-1 crash lands in Ünderland while en route from a superscience costume party. Rather than execute them immediately, he inflicts an unspeakable torture upon them: they're forced to attend his wedding. Only the shadowy, disorganized Ünderground resistance group can help them escape.
When the Guild of Calamitous Intent finally approves Dr. Orpheus for his very own arch nemesis he calls upon old friends The Alchemist and Jefferson Twilight to resurrect their former super-team, The Order of the Triad. While they audition supervillain candidates at the Venture Compound, a jealous Doc isn't about to let Orpheus steal the show. Let loose the Walking Eye!
When the Gargantua-1 Space Station breaks orbit and crashes into a wanted terrorist, Colonel Bud Manstrong becomes a national hero. But did it really happen or is Bud's mother, the indomitable Mrs. Manstrong, behind an insidious plot to assassinate the President? The mysterious blinking band aid on Bud's head might be the key to a mystery only the ghost of Abraham Lincoln and Team Venture can solve.
The Monarch continues to rebuild his villainous empire with the aid of his shadowy new Number 2, Dr. Henry Killinger, but Henchman 21 is suspicious of the deadly foreigner's unctuous charms. Meanwhile, as Dr. Orpheus attempts to exorcise a Japanese demon from Dr. Venture, a mysterious woman from Doc's past resurfaces. And she'd kill to find out where Hank and Dean are.
When Dr. Venture finally succeeds in attaining the holy grail of superscience - the revivification of a human corpse for fun and profit - a washed up gang of wandering former teen sleuths is convinced that the Venture Compound is haunted. Their investigation uncovers something far creepier. Meanwhile, Orpheus shepherds Brock through a crisis of conscience with the help of a New Age shaman and a bizarre tea party.
Dr. Girlfriend finally accepts the Monarch's wedding proposal... if he calls off his grudge with Dr. Venture. He agrees, but things take a turn for the worse when his henchmen mistakenly capture Team Venture, while the Phantom Limb vows not to take his break-up lightly.
A three-month period in the lives of our heroes and villains is chronicled. Dr. Venture recruits college interns to help him complete a project for J.J. in time, but things go awry. Dean makes a life-changing decision after Triana rejects him, and Billy Quizboy acquires a new archenemy.
The Ventures travel into the jungles of Central America to find an invention that has developed a mind of its own.
While the Monarch and his wife attempt to destroy the Venture compound once and for all, the Monarch learns a startling secret about his past. Meanwhile, Twenty-One tries to create a new SPHINX... and inadvertently recruits the members of the old SPHINX.
A figure from Dr. Venture's past haunts him during his annual vacation to Spanikos.
The OSI manage to capture Monstroso and Molotov. But things go horribly wrong and afterward Internal Affairs tries to work out what really happened.
Dean pays a visit to the mystery woman in his life, while Hank and Dermott play a prank on Dr. Venture which leads him on a quest to find his mystery friend and rescue him.
Brock goes undercover to rescue a volunteer undercover operative helping the OSI track down the Council of 13, and ends up in a night club... of doom!
When Rusty is apparently killed by the Monarch, Hatred sends the boys off to live with their godparents, and then turns to Twenty-One for help to infiltrate the Flying Cocoon and recover Rusty's body.
The Ventures are back! And they’re movin’ on up to a deluxe apartment in the sky. But will mo’ money bring mo’ problems? And can The Monarch handle the commute?
A super-widow surfaces and makes Dr. Mrs. The Monarch's job difficult while a criminal genius tries to arch Dr. Venture.
Avant-garde supervillains try to arch Dr. Venture while Hank searches for love in a den of ninjas.
The Guild targets Dr. Venture, but do they have the right man?
The Guild decide to team up with O.S.I. and eliminate a common threat using Dr. Venture as bait.
White and Billy grapple with their archenemy in their old neighborhood; Doc realizes he cannot face his responsibilities alone.