Ultimate Spider-Man will be a unique journey exploring our favorite web-slinger as he teams up with other fan favorite Marvel Super Heroes in never before seen stories with a new life filled with great challenges, new friends, intense action and character growth. Ultimate Spider-Man will tell a coming of age story, where hapless Peter Parker evolves from a naive teen hotshot to a true hero who comes to terms with his origins and abilities. As the storyline begins, Peter Parker has been Spider-Man for just one year. Hes fought villains, saved lives, but still has much to learn about being a super-hero. Now, Nick Fury gives Peter the chance to go to the next level to train to be a real super-hero and become The Ultimate Spider-Man. But before he can do that, Peter will have to learn how to work with a team of fellow teenage super-heroes. Along the way, he will have to navigate challenging relationships with mentors and super-colleagues, and emerge with a better understanding of his parents' legacy and his own destiny.
One year after becoming Spider-Man, a teenage Peter Parker is approached by Nick Fury to train with S.H.I.E.L.D. Spidey turns Fury down, but soon finds that villainous forces may require him to join the big leagues after all.
Spider-Man accepts Nick Fury’s offer to become the Ultimate Spider-Man and meets his new allies of young heroes consisting of Nova, White Tiger, Power Man and Iron Fist. Meanwhile, Norman Osborn orders Doctor Octopus to send the Frightful Four to target Spider-Man. Spider-Man ends up having to get help from his new allies to fight off the Frightful Four.
After a childish argument between Spider-Man and Nova gets their entire team grounded, the super-youths go through S.H.I.E.L.D.'s database of the most wanted supervillains to see who they can defeat and apprehend in order to impress Nick Fury. When the choices Batroc the Leaper, Blizzard, Melter, MODOK, Toad, Whirlwind, and Lady Porcupine prove unpopular, Spider-Man and his team go to Latveria to track down Doctor Doom. The young heroes fairly easily capture Doom, but things take a turn for the worst when Doctor Doom tricks the team into taking one of his Doombots aboard the Helicarrier.
Under the supervision of Osborn, Doctor Octavius obtains a sample of Spider-Man's blood in order to create a creature that rivals the powers of the wall crawler. Meanwhile, Peter attempts to balance his friendship with Harry with his time with his SHIELD teammates.
When Spider-Man meets his idol Iron Man, he receives a specialized gift: the Iron Spider suit. However, Spider-Man experiences difficulty learning how to use the suit and begins to neglect his teammates. Meanwhile, the heroes battle "The Living Laser", who takes advantage of Spider-Man's lack of experience using the new suit.
Taskmaster goes undercover and infiltrates Peter's school to seek out Spider-Man. Spider-Man and White Tiger must put their differences aside and find a way to defeat an opponent who can mimic all of their physical abilities.
Spider-Man agrees to a video interview with budding news reporter Mary Jane Watson, who gets a more exclusive scoop than she could ever have anticipated when Spider-Man and The Incredible Hulk engage in an all-out battle against Zzzax throughout Manhattan.
It is bad enough Spider-Man catches a cold, but things drop from bad to worse when a new Spider-Man dressed in black attempts to replace him. Are his friends right and is his jealousy getting the best of him, or is the new Spider-Man Venom's latest victim?
While on a field trip, Spider-Man and his superhero friends encounter the mighty Thor, who is transformed into a frog by his mischievous half-brother Loki. Now, the heroes must venture to the magical world of Asgard in order to save the nine realms from Loki's wrath.
Spider-Man and Wolverine must overcome clashing personalities and styles in order to defeat Mesmero and Sabretooth.
Venom resurfaces using Harry as his host yet again; this time Harry's neglecting father becomes his main target. While Norman Osborn does not want his potential secret weapon damaged, Spider-Man is confronted with the dilemma of either trying to help Harry on his own or putting his trust in his teammates, who have orders from Fury to finish Venom off.
After a fight with Whirlwind, Spider-Man insists on a weekend off from Nick Fury and S.H.I.E.L.D.. Unfortunately, Doctor Octopus chooses this very time to attack Spider-Man when his job is threatened by Norman Osborn.
Peter Parker scrambles to focus his attention between completing his science fair project with Luke Cage and combatting Juggernaut. In his desperation concerning the first case, he decides to "borrow" one of Dr. Connor's inventions ... which (literally) becomes an even bigger threat to the city.
After being late for training, Spider-Man is faced against an evil super army called Zodiac and their leader, Scorpio, who took over the S.H.I.E.L.D. Helicarrier and set it on self-destruct. Spider-Man and Fury must put their differences aside and fight the new menace as a team.
Spider-Man and his team are put on S.H.I.E.L.D. security detail to protect the all-too-critical-for-his-own-health J. Jonah Jameson from the Beetle, a prospect Spider-Man does not enjoy. Things do get personal when Spider-Man must also protect a highly determined Mary Jane, who is on her way to the Bugle for a job interview, from the high-tech villain.
When Phil Coulson wants the heroes to report to the S.H.I.E.L.D. ice base for winter survival training, Spider-Man and his team sneak off for a vacation on a deserted tropical island that Nova finds under "classy." However, they soon realize something is not right with the island and the Sandman will make sure they never leave.
When Spider-Man and his fellow teenage super heroes cause too much damage in a super villain fight, Nick Fury assigns them to work with the super clean-up company Damage Control. While working with Damage Control, Spider-Man uncovers a villainous mystery.
Hulk smashes back into Spider-Man’s life where he is sick with an alien infection caused by the Phalanx. Spider-Man has no choice but to take Hulk home and keep him hidden from Aunt May while protecting him from the Phalanx.
Loki exacts revenge on Spider-Man by turning him into a pig, just in time for the Asgardian Boar Hunt across New York City. Now, Thor, who knows all too well how it feels to be transformed into a helpless animal, must help Spider-Ham survive.
Flash Thompson stars as Spider-Man in a Midtown High musical production, and gets a taste of what Spider-Man's life is really like when the Trapster mistakes the football jock for the real web-slinger.
When Doctor Octopus takes over Iron Man's armors, Spider-Man and team work to stop his attacks on Oscorp and S.H.I.E.L.D.
Spider-Man loses Captain America's shield and must retrieve it from Doctor Doom.
Aunt May goes on a date with Phil Coulson, Peter's principal and S.H.I.E.L.D. supervisor, and the Beetle returns to continue his evil deeds.
Spider-Man and Miles, tracking the missing pieces of the Siege Perilous, travel to a tropical Pirate dimension where they meet Web Beard, the Spider-Pirate, and encourage him and his old team to work together to save themselves from the dreaded Kraken.
Spider-Man and Kid Arachnid try to prevent Mr. Negative from using the Siege Perilous to drain all the life and color out of the world.
Spider-Man, having collected all of the shards of the Siege Perilous, returns to Miles Morales' universe and confronts Wolf Spider.
Trick-or-treaters start turning into monsters and Spider-Man, Dr. Strange and Ant-Man must team up to stop Baron Mordo.
Spider-Man must team with the former traitor, Scarlet Spider, to stop Doc Ock from reawakening a secret program designed to create evil duplicates of Spider-Man.
Spider-Man and Scarlet Spider have to infiltrate the sunken Hydra Island so Scarlet can destroy the lab that created him.
Spider-Man puts the Triskelion on lockdown when a mysterious villain begins to take out the heroes one at a time.
Spider-Man house sits on Christmas Eve and is forced to team up with Moon Knight to defend the home from the new Mysterio.
Doctor Octopus threatens to harm Aunt May if Spidey ever puts on his mask again; Spider-Man must track down Doc Ock before he has a chance to put his plan into action.
Spider-Man must stop Rhino’s personal vendetta against Spidey’s least favourite Midtown High classmate: Flash Thompson.
Spider-Man and Hawkeye join forces when the Beetle returns to New York City.
Spider-Man gets trapped with six of his most dangerous foes, including Rhino; Kraven the Hunter; Lizard; Electro; Beetle; and a secret sixth member.
Spider-Man accepts an invitation from Boston to become the city's official hero.
The Green Goblin returns and tries to make Spider-Man into his perfect weapon, but Carnage has other ideas for the duo.
The security system at Aunt May's home becomes dangerous.
The team respond to a message from J.J. Jameson requesting for help to rescue his son who has disappeared on a mission working on the moon
A disgruntled Stark Industries scientist named Michael Tan develops and envelops himself in a swarm of self-replicating nanobots. Now Spider-Man must work with Iron Man to contain Swarm.
Using a Norn Stone, Loki shrinks Spider-Man's team while looking for Thor. Nick Fury has Spider-Man's team placed in the Helicarrier's D.A.Y.C.A.R.E. area while S.H.I.E.L.D. continues to look for Thor. With Thor also having been shrunk, Spider-Man's team must find a way to help Thor fight Loki and the Destroyer Armor and return to normal size.
Spider-Man travels to the mystical city of K’un L’un to help Iron Fist fulfill his destiny. But The Scorpion plans to destroy them both.
Spider-Man and The Hulk switch minds, leading to lots of craziness and a clobberin’ from The Thing of The Fantastic Four.
Spider-Man, Mary Jane, Harry and Stan the Janitor have to descend into the sewer tunnels beneath Midtown High to track down the Lizard.
Spider-Man and Power Man infiltrate Zodiac's base to discover what happened to Power Man's parents
Mutant terrorist Arcade becomes one of S.H.I.E.L.D.'s biggest threats. Spidey must change all of the rules to defeat this cyber nemesis, but he can't do it alone. He teams up with Captain America and Wolverine to beat Arcade at his own game, but will it be enough before it's game over?
It's Halloween for Marvel's Ultimate Spider-Man, but there's no time for Spider-Man and his friends to trick-or-treat when they find themselves attacked by evil vampires led by Dracula himself.
Spidey's only hope of stopping a world takeover is to team up with Nick Fury's secret team of super-powered monsters, The Howling Commandos. Led by Jack Russell, aka Werewolf by Night, The Howling Commandos include vampire hunter Blade, The Living Mummy, Frankenstein's Monster and Man-Thing.
Sandman proves he might not be the biggest bad after all. He's given the chance to start all over and Spidey must mentor his former foe as he struggles against his old instincts. What side will Sandman ultimately choose, hero or villain?
Doc Ock launches a surprise attack on Spider-Man and the heroes. They soon find themselves in one of the most challenging battles of the season when they're up against the newly reformed Sinister Six. Norman Osborn also returns as Iron Patriot despite Ock's alternate plans for him.