Based on the hit movie of the same name, Uncle Buck is a fun-loving but irresponsible guy who needs a job and a place to stay. His brother and sister-in-law need some help around the house. And they just might be the answer to each other's problems.
Uncle Buck is a charismatic hustler who has gotten by on his charm for years. But when his brother Will and sister-in-law Alexis move to town and need help with their kids, he steps up to become their “manny.” Their lives will never be the same.
Sibling rivalry gets the best of Will when Buck really hits it off with his architect office buddies. Rivalry of another kind spurs Alexis to drag her reluctant kids into a lip-sync battle hosted by the snooty president of her college sorority alumna.
Alexis is convinced that Buck is to blame for Miles' new, impulsive attitude after she catches him attempting a risky stunt for his Youtube channel. With Miles' punishment looming, Buck decides to throw a "going to jail" party while Mom and Dad are out, but unfortunately a creepy neighbor calls the cops and ruins their celebration. Buck, Miles, Tia and Maizy seek revenge and end up in a prank war.
Buck and his buddy Cy have a tradition of watching the Bulls games on TV together with Buck's lucky basketball beside them (or the Bulls lose). But Buck's multi-tasking skills are pushed to the limit as Tia, Miles and Maizy all have separate crises on the night of a big game, and Will and Alexis are out celebrating their anniversary.
Will and Alexis return from a day out to find the house in complete chaos, with a broken window, a wading pool full of ice, a disabled wood chipper and a small fire burning in the yard. But when they try to get to the bottom of things, Buck and the kids all have different versions about what really happened.