Former Syracuse, New York, police detective Carrie Wells has hyperthymesia, a rare medical condition that gives her the ability to visually remember everything. She reluctantly joins the New York City Police Department's Queens homicide unit after her former boyfriend and partner asks for help with solving a case. The move allows her to try to find out the one thing she has been unable to remember, which is what happened the day her sister was murdered.
Eddie Martin, Carrie's long-lost husband, pays a visit to Major Crimes while investigating a meth crew that is involved in something more nefarious than dealing drugs.
Carrie and Al are assigned to transport the star witness in a high profile securities fraud case to Miami, while attempting to evade the killers on their trail.
The killing of a young jazz prodigy leads Carrie and the team into the halls of a competitive music conservatory and the underbelly of the city's jazz club scene.
The Major Crimes team learn that a deli employee's murder is linked to a foreign criminal organization that has the ability to cripple the world's financial markets.
Things heat up for Carrie when an old flame and a murder investigation lead the Major Crimes team to Atlantic City, NJ.
Carrie and Al suspect that a cameraman's death during a convenience store robbery may be more than a random act of violence.
Major Crimes determines that the kidnapping of a prominent scientist's son was not a crime of opportunity but rather a calculated scheme for revenge.
Suspects are plentiful in a case of a murdered aerospace engineer, the Major Crimes team learns that the victim was working on a billionaire's top secret space mission.
Carrie, Al and a captured criminal hole-up in an abandoned precinct as a sinister storm approaches, with their captive's violent crew hot on their trail.
Carrie and Al investigate the world of high-stakes video games and corporate espionage after a man is found dead inside a haunted-house attraction.
Carrie and All receive new information in the cold case of a missing surgeon, putting them on the trail of two con-artists.
Captain Russo is suspected in the murder of an informant, leading Carrie and Al in a cat-and-mouse game with a corrupt former cop.
Carrie and Al’s reputation for closing cases results in an offer to join the Major Crimes Section of the NYPD. But when their first case – a high-profile child kidnapping – hits close to home for Carrie, it leaves her wondering if a move from Queens to Manhattan is what’s best for her.
Carrie goes undercover with a team of bank robbers when The Major Crimes Section gets a lead on the gang’s leader, a notorious thief who rarely shows his face.
Carrie and Al are unable to discern why a businessman was murdered in his hotel room until it’s discovered that his death was collateral damage in a larger plot to assassinate a diplomat.
When the scientist who helped Carrie understand her memory abilities is murdered, she must track down other people with the same skill in the hopes that one of them holds the key to finding the killer.
Carrie and Al’s latest case – the murder of an Afghani cab driver – has the potential to turn into a matter of national security when it’s discovered that the victim was a government informant.
When a young man is found dead in an expensive sports car he was delivering to a diplomat, each clue leads Carrie and Al to yet another possible motive for the murder.
The murder of an urban explorer leads Carrie and Al to not only search for the killer, but to pick up the trail of clues the victim was following on the hunt for a treasure supposedly hidden under the streets of New York.
After a wealthy couple is murdered, Carrie and Al pose as a married couple to lure in the killer, who Al believes is linked to a series of unsolved homicides he once investigated.
Carrie catches a deadly assassin who has eluded her before, but must put her personal vendetta aside when it’s revealed that the woman has vital information to prevent a terrorist attack on New York City.
The murder of a prominent lawyer leads Carrie and Al to reexamine a rape case that moved Manhattan thirteen years before. Soon, they realize that the case was not as clear cut as it was portrayed by the media, and an innocent man may have been wrongfully convicted.
A murdered body washes ashore in the Hamptons, and Carrie and Al's boss offers them a "paid vacation" in his beautiful Southampton cottage, in order to help local law enforcement find the killer, who may or may not be related to a previous serial killer.
When Carrie and Elliott are attending a party sponsored by the mayor, a group of criminals seizes control of the building, and demand a hefty ransom. It is up to Carrie to thwart their plans by playing from the Die Hard book.
Carrie's high school reunion is suddenly cut short when an alum shows up dead. Carrie has to remember back 22 years to understand the events that led to this crime.
Carrie and Al assist the Secret Service with a murder investigation that has ties to a counterfeiting ring run by an assassin.
Carrie and Al investigate when a championship boxer appears to have been beaten to death without making an effort to defend himself.
After releasing a salacious story about the director of the NSA, a reporter is murdered; Agent Simms comes back to help Carrie; Al reconnects with an ex who might be able to assist with the case.
When Carrie recognizes a murdered city official as someone she played poker with at an underground casino, she puts her career on the line by admitting her illegal activities and volunteers to go back to the tables undercover.
Carrie and Al must find the connection between a murdered coast guard officer, a celebrity chef who threw him out of his restaurant and a missing block of C-4 before the explosives are used.
Carrie conducts an investigation off the books when Al becomes the prime suspect in the murder of a parolee he helped put away.
When one of Eliot's oldest friends, the campaign manager for a mayoral candidate, is murdered, he is forced to face his past and current demons as Carrie and Al work to uncover the killer.
Carrie and Al's investigation into the death of a college dropout takes a surprising turn when they discover he had been living in an off-the-grid community on an abandoned island near Manhattan.
Carrie and Al dig into the secrets of students and faculty at an elite prep school when a high-powered CEO and father of one of the students is murdered.
When Homeland Security takes over a bombing investigation from Major Crimes, Carrie doubts their conclusion that it's tied to terrorism and secretly continues her own investigation. Meanwhile, Webster makes friends with Murray's daughter.
Carrie and Al investigate the murder of a high-end matchmaking service employee, but each secret they uncover in the victim's life only serves to create a new possible suspect and motive.
Carrie and Al delve into the disturbing - and dangerous - world of celebrity obsession when a television star is found murdered in his dressing room.
Carrie is unable to utilize her perfect memory when an assassin doses her with a deadly poison that attacks her brain, leaving Al on a desperate hunt for the antidote.
A murder reunites former detective Carrie Wells with her ex-boyfriend and colleague; Carrie must use her rare ability to help solve the case.
Carrie must put aside memories of her sister's death to help a young murder witness lead the police to a killer.
Carrie tries to uncover the truth when a hotel maid accused of murder says she was defending herself against attempted rape.
After an explosion destroys a crime scene, Carrie's memories become essential to the investigation.
When Al’s ex-partner is gunned down and the investigation reveals he may have been a dirty cop, Carrie must decide how to support him without getting too close
Carrie and Al’s investigation into the murder of a hard-partying heiress takes an unexpected turn when they discover that the woman apparently didn’t exist until 18 months earlier.
Carrie's investigation into the death of her sister moves forward, but her inability to let go may hinder the search for a missing infant whose father was murdered.
Carrie and Al investigate the death of a public defender, only to discover that the killer has a larger plan which may lead to a second murder.
Al and Carrie investigate the murder of a teen who seemed to have no enemies. Meanwhile, Carrie looks to her estranged aunt for help with the investigation into her sister's murder.
When a second murder suddenly occurs at an active crime scene, Al and Carrie must wade through hundreds of bystanders to uncover if it was retribution or an unrelated attack.
Carrie and Al link the death of a ghost hunter to a discovery he made on a recent assignment.
When a construction worker with a promising future is murdered, Carrie and Al wonder if his ties to the mob were the cause of his death or an unrelated coincidence.
A routine investigation into a college student’s death takes a disturbing turn for Carrie when a suspect makes a dangerous move to outwit her memory.
A serial killer with knowledge of Carrie’s memory abilities taunts the Queens PD as his list of victims grows.
When a key witness in his murder case vanishes before testifying, Al scrambles to find her before the suspect walks free.
Carrie and Al are at a loss to explain how a murder victim mysteriously appeared in an empty ballpark.
Al and Carrie are forced to the sidelines by a negotiator when the father of a suspect that Roe shot takes members of the Queens PD, including Nina, hostage in a desperate quest for justice.
When Carrie’s latest case is stalled by a powerful family’s influence, she receives assistance from a lawyer who may be the mysterious caller who orchestrated a series of sniper attacks.
Carrie’s personal and professional lives collide when her boyfriend, the son of a mob boss, is revealed to have ties to suspects in a murder investigation.
Carrie and Al must get inside the mind of a deranged conspiracy theorist before he sets off a series of bombs.
When Carrie's obsessed admirer turns up dead, she must locate the killer while deflecting attention from the prime suspect: her.
Carrie follows the trail of her sister's killer to Syracuse, where the murderer may have struck again.